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# A frameshift variant in ADAP1 more than triples serious mental illness risk in Colombia
- URL: https://www.coios.me/a-frameshift-variant-in-adap1-more-than-triples-serious/
- Published: 2026-09-29T12:35:33.000Z
- Updated: 2026-09-29T21:03:33.000Z
- Description: Exome sequencing of 21,958 cases and 19,826 controls in the Paisa founder population of Colombia found seven genes associated transdiagnostically with serious mental illness, led by an ADAP1 frameshift variant that raises risk of schizophrenia and bipolar disorder more than threefold.
- Author: Daniel Ryan
- Tags: Weighing data and models, What linked data reveals, Mental health, Colombia, #preprint, #new, #item, #source-2026-09

Researchers sequenced the exomes of 21,958 people with serious mental illness or severe major depressive disorder and 19,826 controls from the Mision Origen biobank in the Paisa genetic isolate of Colombia, testing predicted deleterious variants transdiagnostically. Seven genes were associated, five of them newly implicated, with the association at four driven by variants common in the Paisa through a founder effect. The strongest signal, a frameshift variant in ADAP1 at an allele frequency of about 0.4%, raised risk of both schizophrenia and bipolar disorder more than threefold, and carriers differed from other cases on psychotic, manic and cognitive phenotypes extracted from electronic health records.

*Why it is interesting: A founder population with linked records yields a variant of intermediate frequency and large effect, between what common-variant and ultra-rare-variant studies reach.*

Source

[medRxiv, 27 September 2026](https://doi.org/10.64898/2026.09.25.26363706?ref=coios.me)

DOI

10.64898/2026.09.25.26363706

Type

Preprint

Design

Exome-sequencing case-control association study, 21,958 cases and 19,826 controls, Paisa genetic isolate, Colombia

Verdict

New finding

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)

Driver

[Mental health](https://www.coios.me/d-mental-health/)