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# A multicancer blood test did not cut late-stage cancer diagnoses in 142,250 adults
- URL: https://www.coios.me/a-multicancer-blood-test-did-not-cut-late-stage-cancer/
- Published: 2026-09-26T09:54:53.000Z
- Updated: 2026-09-26T10:09:53.000Z
- Description: In the NHS-Galleri randomised trial of 142,250 adults aged 50 to 77 in England, three annual rounds of a blood-based multicancer early-detection test alongside usual care did not reduce stage III or IV cancer incidence across 12 prespecified cancers (rate ratio 1.03).
- Author: Daniel Ryan
- Tags: Healthcare today, Cancer, Innovation in treatment, United Kingdom, #peer-reviewed, #new, #item, #source-2026-09

The NHS-Galleri trial randomised 142,250 adults aged 50 to 77 in England to annual blood-based multicancer screening or usual care, with up to three screening rounds. Stage III or IV cancer incidence across 12 prespecified cancers did not differ between the groups (rate ratio 1.03, 95% CI 0.92 to 1.14). Stage IV cancer alone, a secondary end point, was lower in the screened group (rate ratio 0.86, 95% CI 0.74 to 1.00), and trial-related adverse events affected under 1% of participants.

*Why it is interesting: A large randomised trial of a multicancer blood test finds no reduction in late-stage diagnoses on its primary end point, with a secondary signal for stage IV alone.*

Source

[New England Journal of Medicine, 22 September 2026](https://doi.org/10.1056/nejmoa2505723?ref=coios.me)

DOI

10.1056/nejmoa2505723

Type

Peer-reviewed article

Design

Randomised controlled trial, 142,250 adults aged 50-77 in England, three annual screening rounds plus at least 12 months' follow-up

Verdict

New finding

Driver

[Cancer](https://www.coios.me/d-cancer/)

Driver

[Innovation in treatment](https://www.coios.me/d-treatment-innovation/)