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# A US CADASIL cohort finds raised cognitive impairment across all genetic risk tiers
- URL: https://www.coios.me/a-us-cadasil-cohort-finds-raised-cognitive-impairment/
- Published: 2026-09-24T08:27:45.000Z
- Updated: 2026-09-24T09:39:46.000Z
- Description: Baseline data from the first US CADASIL cohort, 343 genetically confirmed NOTCH3 carriers and 116 non-carrier relatives at a median age of 47.9 years, found adjusted odds of a worse Clinical Dementia Rating of 2.55 to 5.08 in carriers across all three genetic risk tiers.
- Author: Daniel Ryan
- Tags: Healthcare today, Dementia, United States, #preprint, #new, #item, #source-2026-09

The US CADASIL Consortium recruited adults from families carrying NOTCH3 variants at 12 sites between October 2022 and January 2025, assessing them with harmonised cognitive, physical, MRI, genetic and proteomic protocols. Among 343 confirmed carriers, three quarters fell into the high genetic risk tier, and adjusted odds of a worse Clinical Dementia Rating category against 116 non-carrier relatives ranged from 2.55 to 5.08\. Median age was 47.9 years and 91.4% of participants were White, in a preprint.

*Why it is interesting: A single-cause cohort offers a controlled reference point for the vascular contribution to cognitive impairment, which population counts separate poorly from Alzheimer pathology.*

Source

[medRxiv, 22 September 2026](https://doi.org/10.64898/2026.09.20.26363512?ref=coios.me)

DOI

10.64898/2026.09.20.26363512

Type

Preprint

Design

Cross-sectional baseline analysis of a 12-site US longitudinal cohort, 459 analysed (343 NOTCH3 carriers, 116 non-carrier family controls), enrolled October 2022 to January 2025

Verdict

New finding

Driver

[Dementia](https://www.coios.me/d-dementia/)