> ## Content Index
> Fetch the complete content index at: https://www.coios.me/llms.txt
> Use this file to discover other available public pages before exploring further.

# An Amish founder-population cohort links genomes and cognition in 3,978 older adults
- URL: https://www.coios.me/an-amish-founder-population-cohort-links-genomes-and/
- Published: 2026-09-21T08:05:46.000Z
- Updated: 2026-09-21T08:05:46.000Z
- Description: The Collaborative Amish Aging and Memory Project has enrolled 3,978 older Amish adults in Ohio and Indiana, 2,928 with consensus-adjudicated cognitive status, alongside multigenerational pedigrees, whole-genome sequencing and plasma biomarkers, and reports no findings beyond its composition.
- Author: Daniel Ryan
- Tags: Power of data, What linked data reveals, Dementia, Biotechnology against inherited risk and ageing, United States, #preprint, #new, #data, #source-2026-09

CAAMP is a longitudinal study of cognition and age-related traits in Amish communities across sites in Ohio and Indiana. Of 3,978 participants (mean age 78.6, 59.1% female), 2,928 have adjudicated cognitive status, of whom 66.6% are unimpaired, 9.9% have mild cognitive impairment, 8.9% Alzheimer disease and 4.5% another cognitive impairment. The resource links clinical and cognitive assessment to genealogies, genotyping, whole-genome sequencing and plasma biomarkers.

*What you could now answer: A founder population with deep pedigrees and sequencing offers a route to genetic factors in dementia risk and protection.*

Source

[medRxiv](https://doi.org/10.64898/2026.09.17.26363351?ref=coios.me)

Coverage

Amish communities in Ohio and Indiana, United States; 3,978 participants, mean age 78.6; enrolment ongoing, start year not stated

Granularity

Individual-level clinical and cognitive assessment with consensus-adjudicated diagnosis, pedigree, genome-wide genotype, whole-genome sequencing, plasma biomarkers; repeat visits for subsets

Latency

not stated

Access

not stated

Change

New source

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)

Driver

[Dementia](https://www.coios.me/d-dementia/)

Driver

[Biotechnology against inherited risk and ageing](https://www.coios.me/d-biotechnology/)