> ## Content Index
> Fetch the complete content index at: https://www.coios.me/llms.txt
> Use this file to discover other available public pages before exploring further.

# An automated splenic measure on cardiac PET tracked later major cardiovascular events
- URL: https://www.coios.me/an-automated-splenic-measure-on-cardiac-pet-tracked-later/
- Published: 2026-09-21T08:01:58.000Z
- Updated: 2026-09-21T08:01:58.000Z
- Description: In 16,650 patients having stress rubidium-82 cardiac PET at six sites, an automated splenic ratio was independently associated with later major cardiovascular events, most strongly among the 6,508 whose scans showed no ischaemia (HR 1.54, 95% CI 1.26-1.88).
- Author: Daniel Ryan
- Tags: Healthcare today, Cardiovascular disease, AI in medicine, United States, #peer-reviewed, #new, #item, #source-2026-09

The authors applied an automated algorithm to derive the splenic ratio, a marker of how adequately a patient was stressed pharmacologically, in 16,650 patients from the REFINE PET registry followed for a median 3.4 years. A high splenic ratio was associated with major adverse cardiovascular events in the testing cohort (HR 1.19, 1.06-1.34), and more strongly where perfusion was otherwise reassuring (HR 1.54, 1.26-1.88). The measure needs no manual input and held after adjustment for clinical and imaging covariates.

*Why it is interesting: A by-product of an existing scan separates risk among patients whose imaging is otherwise read as reassuring.*

Source

[Cardiovascular Research, 19 September 2026](https://doi.org/10.1093/cvr/cvag184?ref=coios.me)

DOI

10.1093/cvr/cvag184

Type

Peer-reviewed article

Design

Retrospective multicentre cohort, 16,650 patients at six REFINE PET registry sites, median follow-up 3.4 years

Verdict

New finding

Driver

[Cardiovascular disease](https://www.coios.me/d-cardiovascular/)

Driver

[AI in medicine](https://www.coios.me/d-ai-medicine/)