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# AT2-stimulating antihypertensives were linked to less dementia in two US cohorts
- URL: https://www.coios.me/at2-stimulating-antihypertensives-were-linked-to-less/
- Published: 2026-09-20T00:06:37.000Z
- Updated: 2026-09-20T00:42:44.000Z
- Description: In 1.6 million Medicare beneficiaries and 80,267 Vanderbilt patients aged 65 and over with hypertension, incident Alzheimer's disease and related dementias were less common among users of angiotensin II receptor-stimulating than receptor-inhibiting antihypertensives (6.7% against 8.2% in Medicare).
- Author: Daniel Ryan
- Tags: Healthcare today, Dementia, United States, #preprint, #confirms, #item, #source-2026-09

A new-user, active-comparator cohort study compared adults aged 65 and over with hypertension taking predominantly receptor-stimulating antihypertensives (ARBs, dihydropyridine calcium channel blockers, thiazides) with those taking receptor-inhibiting classes (ACE inhibitors, beta blockers, non-dihydropyridine calcium channel blockers), in US Medicare claims (n=1,596,034) and the Vanderbilt electronic health record (n=80,267). Over roughly seven years, incident Alzheimer's disease and related dementias were lower in the stimulating group in both sources, at 6.7% against 8.2% in Medicare. The analysis used propensity-score matching and Cox models with time-dependent covariates, but it is observational and has not yet been peer reviewed.

*Why it is interesting: Tests a single-cohort pharmacoepidemiological signal on antihypertensive class and dementia in a structurally independent data source, and the direction holds.*

Source

[medRxiv, 17 September 2026](https://doi.org/10.64898/2026.09.11.26362859?ref=coios.me)

DOI

10.64898/2026.09.11.26362859

Type

Preprint

Design

Retrospective new-user, active-comparator cohort with propensity-score matching in two independent US sources: Medicare claims 2015–2023 (n=1,596,034) and Vanderbilt EHR (n=80,267), \~7 years' follow-up

Verdict

Confirms prior evidence

Driver

[Dementia](https://www.coios.me/d-dementia/)