> ## Content Index
> Fetch the complete content index at: https://www.coios.me/llms.txt
> Use this file to discover other available public pages before exploring further.

# Black participants were 4% of Black and White enrolment in landmark HCM trials
- URL: https://www.coios.me/black-participants-were-4-of-black-and-white-enrolment-in/
- Published: 2026-09-29T12:50:16.000Z
- Updated: 2026-09-29T21:00:16.000Z
- Description: Across 13 landmark hypertrophic cardiomyopathy trials, 70 of 1,780 Black or White participants were Black, a pooled share of 3.98% against a population expectation of 16.5%, and site geography and eligibility thresholds did not account for the shortfall.
- Author: Daniel Ryan
- Tags: Healthcare today, Heart and stroke, Health funding and inequalities, United States, #preprint, #new, #item, #source-2026-09

The authors screened 197 registered interventional hypertrophic cardiomyopathy trials, identified 32 landmark trials and extracted race for 13, then compared the Black share of participants with US population, trial site-catchment and echocardiographic disease-prevalence expectations. The pooled Black share was 3.98% (95% CI 2.68 to 5.86) against 16.5% in the adult population, a participation-to-prevalence ratio of 0.24\. Site networks reached 63.7% of Black US adults and predicted 26.4% enrolment, while quantitative eligibility thresholds closed only 2.0% of the gap.

*Why it is interesting: Enrolment in trials for a condition at least as common in Black as in White Americans fell far below population share, and site geography and eligibility thresholds did not close the gap.*

Source

[medRxiv, 27 September 2026](https://doi.org/10.64898/2026.09.24.26363977?ref=coios.me)

DOI

10.64898/2026.09.24.26363977

Type

Preprint

Design

Meta-analysis of participant demographics from 13 of 32 landmark interventional hypertrophic cardiomyopathy trials (1,780 Black or White participants), with geospatial site-catchment and NHANES eligibility modelling

Verdict

New finding

Driver

[Heart and stroke](https://www.coios.me/d-cardiovascular/)

Driver

[Health funding and inequalities](https://www.coios.me/d-health-inequality/)