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# Daraxonrasib is estimated at $500,637 per QALY in pancreatic cancer at US launch price
- URL: https://www.coios.me/daraxonrasib-is-estimated-at-500-637-per-qaly-in-pancreatic/
- Published: 2026-09-20T00:08:13.000Z
- Updated: 2026-09-20T00:42:06.000Z
- Description: A modelled economic evaluation of daraxonrasib in previously treated metastatic pancreatic adenocarcinoma estimated 0.506 additional QALYs at an incremental cost of $253,171, or $500,637 per QALY at the $39,800 monthly launch price, in a preprint not yet peer reviewed.
- Author: Daniel Ryan
- Tags: Healthcare today, Cancer, New medicines, United States, #preprint, #new, #item, #source-2026-09

The authors reconstructed individual patient data from the published Kaplan-Meier curves of the RASolute 302 trial and ran a three-state partitioned survival model comparing daraxonrasib with investigator's-choice chemotherapy in previously treated metastatic pancreatic adenocarcinoma. In the RAS G12 population the drug added 0.652 life-years and 0.506 QALYs at an incremental cost of $253,171, giving $500,637 per QALY, and none of 5,000 simulations fell below $200,000 per QALY. Prices of $14,060 and $17,730 per 30 days would meet thresholds of $150,000 and $200,000 per QALY respectively.

*Why it is interesting: Sets the US launch price of a new pancreatic cancer drug against conventional cost-effectiveness thresholds of $150,000 to $200,000 per QALY, from reconstructed rather than original trial data.*

Source

[medRxiv, 17 September 2026](https://doi.org/10.64898/2026.09.16.26363246?ref=coios.me)

DOI

10.64898/2026.09.16.26363246

Type

Preprint

Design

Partitioned survival cost-effectiveness model using reconstructed patient data from the phase 3 RASolute 302 trial (RAS G12 n=459; full randomised n=500), US health sector perspective, 2026 dollars

Verdict

New finding

Driver

[Cancer](https://www.coios.me/d-cancer/)

Driver

[New medicines](https://www.coios.me/d-new-medicines/)