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# Depression was associated with 65% higher cardiometabolic disease incidence at 15 years
- URL: https://www.coios.me/depression-was-associated-with-65-higher-cardiometabolic/
- Published: 2026-10-04T06:38:15.000Z
- Updated: 2026-10-04T07:36:15.000Z
- Description: In 1858 Dutch adults followed for 15 years, lifetime major depressive disorder was associated with a 65% higher rate of incident cardiometabolic disease (HR 1.65, 95% CI 1.30 to 2.11), with comparable effect sizes across atypical, anhedonic and typical symptom profiles.
- Author: Daniel Ryan
- Tags: Healthcare today, Mental health, Netherlands, #peer-reviewed, #refines, #item, #source-2026-10

The Netherlands Study of Depression and Anxiety followed 1858 adults with lifetime major depression or no depression, all free of cardiometabolic disease at baseline, for 15 years, establishing incidence from self-report, medication use and glucose. Incidence was 21.3 per 1000 person-years, and depression carried a hazard ratio of 1.65 against controls after adjustment for sociodemographic and lifestyle factors. Atypical energy-related symptoms, anhedonia and typical symptoms showed comparable effect sizes, with only atypical symptoms separately associated with incident diabetes.

*Why it is interesting: The study tests whether inflammation-linked symptom profiles account for depression's cardiometabolic risk, and finds comparable effects across profiles.*

Source

[Journal of Affective Disorders, 2 October 2026](https://doi.org/10.1016/j.jad.2026.122580?ref=coios.me)

DOI

10.1016/j.jad.2026.122580

Type

Peer-reviewed article

Design

Prospective cohort (NESDA), n=1858 without baseline cardiometabolic disease, 15-year follow-up, Cox models

Verdict

Refines prior evidence

Driver

[Mental health](https://www.coios.me/d-mental-health/)