> ## Content Index
> Fetch the complete content index at: https://www.coios.me/llms.txt
> Use this file to discover other available public pages before exploring further.

# Dexamphetamine persists longer than methylphenidate over 12 months in adults with ADHD
- URL: https://www.coios.me/dexamphetamine-persists-longer-than-methylphenidate-over-12/
- Published: 2026-10-16T13:05:13.000Z
- Updated: 2026-10-17T08:14:42.000Z
- Description: Among adults starting stimulants for ADHD, median time to switching or stopping was 33.1 weeks for dexamphetamine and 15.0 weeks for methylphenidate.
- Author: Daniel Ryan
- Tags: Behavioural science, Adherence and persistence, #peer-reviewed, #new, #item, #source-2026-10, #score-65

The study compared 12-month persistence of methylphenidate (MPH) and dexamphetamine (dAMP) in 12,995 adults with ADHD, 49% female. Persistence was time to switching stimulant class, starting a non-stimulant, or discontinuing, modelled with mixed-effects Cox regression. Median time-to-transition was 33.1 weeks for dAMP and 15.0 weeks for MPH. MPH had a 45% higher hazard of non-persistence (HR 1.45, 95% CI 1.36-1.55). Hyperactive/impulsive presentation and objective impulsivity predicted earlier transition (HR 1.14 and 1.05). The advantage of dAMP grew with higher objective hyperactivity (interaction HR 1.09); treatment was not randomised.

*Why it is interesting: Persistence differs by more than twofold in median duration between two first-line stimulants in the same cohort. Objectively measured activity and impulsivity identify who stops earliest.*

Source

[Acta Psychiatrica Scandinavica, 15 October 2026](https://doi.org/10.1111/acps.70150?ref=coios.me)

Paper

Stimulant Persistence in Adult ADHD : A Retrospective Analysis of a Large Clinical Cohort

Authors

Wettstein R, Pirgon E, Kroesen J, Navarro‐Ovando V, Kroesen JC, Mathôt R et al.

DOI

10.1111/acps.70150

Type

Peer-reviewed article

Design

Retrospective multicentre clinical cohort, n=12,995 adults, mixed-effects Cox model, 12-month persistence

Verdict

New finding

Driver

[Adherence and persistence](https://www.coios.me/d-adherence/)

Free full text

[Free to read at the publisher](https://doi.org/10.1111/acps.70150?ref=coios.me)