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# Early-onset colorectal cancer shows distinct molecular profile but mixed survival
- URL: https://www.coios.me/early-onset-colorectal-cancer-shows-distinct-molecular/
- Published: 2026-09-11T16:52:26.000Z
- Updated: 2026-09-11T16:52:26.000Z
- Description: A scoping review of 46 studies from 22 countries found early-onset colorectal cancer (≤50 years) had more MSI/dMMR tumours and less BRAF V600E than late-onset disease, while survival differences varied across populations and tracked mainly with stage at presentation.
- Author: Daniel Ryan
- Tags: Healthcare today, Early-onset cancer, rising or better found, World, #peer-reviewed, #refines, #item

This scoping review synthesised contemporary evidence on early-onset colorectal cancer (EOCRC, ≤50 years) across 46 observational studies from 22 countries. EOCRC showed higher prevalence of MSI/dMMR tumours (6.0–33.3%) and lower BRAF V600E (2.0–10.0%) than late-onset disease, with limited evidence of CMS1 and CTNNB1 enrichment. Survival differences were heterogeneous across study populations, but stage at presentation was the consistent predictor; advanced-stage disease carried worse outcomes regardless of age group.

*Why it is interesting: Refines understanding of whether early-onset colorectal cancer is a distinct biological entity or mainly a detection problem; molecular differences exist but heterogeneous survival suggests stage and healthcare access matter more than age-related biology.*

Source

[Journal of gastrointestinal cancer, 2026-09-09](https://doi.org/10.1007/s12029-026-01558-z?ref=coios.me)

DOI

10.1007/s12029-026-01558-z

Type

Peer-reviewed article

Design

Scoping review, 46 studies from 22 countries, 2019–2024

Verdict

Refines prior evidence

Driver

[Early-onset cancer, rising or better found](https://www.coios.me/d-early-onset-cancer/)