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# Early-onset colorectal tumours show more stromal cells and distinct gene expression
- URL: https://www.coios.me/early-onset-colorectal-tumours-show-more-stromal-cells-and/
- Published: 2026-11-08T13:02:34.000Z
- Updated: 2026-11-08T14:11:35.000Z
- Description: Colorectal tumours from younger adults held more stromal cells and expressed more long non-coding RNAs and epithelial-to-mesenchymal transition genes.
- Author: Daniel Ryan
- Tags: Health today, Cancer, #peer-reviewed, #new, #item, #source-2026-11, #score-62

The study asked whether early-onset colorectal cancer is biologically distinct from average-onset disease. Researchers mapped the transcriptome of colorectal tumours from patients across the age continuum. Tumours from younger adults contained more stromal cells than those from older adults. They also showed higher expression of long non-coding RNAs and of genes associated with epithelial-to-mesenchymal transition. The work describes differences in tumour gene expression by age and does not test what causes them.

*Why it is interesting: The incidence of early-onset colorectal cancer is rising, but whether it is biologically distinct is unclear. Evidence that these tumours differ in cellular make-up and gene expression bears directly on that question.*

Source

[Nature Medicine, 4 November 2026](https://www.nature.com/articles/s41591-026-04771-2?ref=coios.me)

Type

Peer-reviewed article

Design

Cross-sectional tumour transcriptomic atlas of colorectal cancers across the adult age continuum; sample size and years not stated in the abstract

Verdict

New finding

Driver

[Cancer](https://www.coios.me/d-cancer/)