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# Epigenetic clock changes correspond inconsistently to clinical changes in ageing studies
- URL: https://www.coios.me/epigenetic-clock-changes-correspond-inconsistently-to/
- Published: 2026-10-26T23:40:27.000Z
- Updated: 2026-10-27T07:06:24.000Z
- Description: In human geroscience intervention studies, epigenetic-clock changes matched clinical-outcome changes inconsistently, and no study validated a clock as a surrogate.
- Author: Daniel Ryan
- Tags: Tomorrow's world, Slowing ageing itself, World, #peer-reviewed, #refines, #item, #source-2026-10, #score-82

This systematic review asked whether intervention-induced changes in DNA-methylation clocks match clinical outcome changes in human geroscience studies. Twenty-six studies were included: 13 comparative and 13 single-arm pre-post designs. Fifteen were mixed, six indeterminate and four jointly inconclusive; one uncontrolled study was uniformly concordant for intermediate outcomes. No comparative study or study of patient-important outcomes was uniformly concordant, and none validated a clock as a surrogate endpoint. Eleven studies assessed individual-level associations, responder differences or mediation, but clear findings were isolated and not replicated. No combination of intervention, clock and outcome allowed meta-analysis, and certainty of evidence was very low throughout.

*Why it is interesting: The review tests whether epigenetic clocks can stand in for clinical outcomes in ageing intervention studies. Favourable signals were mainly in selected intermediate outcomes, and clocks remain exploratory rather than validated surrogates.*

Source

[Experimental Gerontology, 24 October 2026](https://doi.org/10.1016/j.exger.2026.113367?ref=coios.me)

Paper

Concordance between changes in epigenetic clocks and changes in clinical outcomes in geroscience intervention trials: A systematic review

Authors

Yi M, Li M, Li H, Gui Y, Wang Z

DOI

10.1016/j.exger.2026.113367

Type

Peer-reviewed article

Design

Systematic review of 26 human geroscience intervention studies (13 comparative, 13 single-arm pre-post) reporting paired DNA-methylation clock and clinical outcome change, with risk-of-bias and GRADE certainty assessment

Verdict

Refines prior evidence

Driver

[Slowing ageing itself](https://www.coios.me/d-ageing/)

Free full text

[Free to read at the publisher](https://doi.org/10.1016/j.exger.2026.113367?ref=coios.me)