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# FAP relatives found by family screening had a median SMR of 0.66, symptomatic cases 11.09
- URL: https://www.coios.me/fap-relatives-found-by-family-screening-had-a-median-smr-of/
- Published: 2026-09-20T00:08:57.000Z
- Updated: 2026-09-20T00:42:37.000Z
- Description: In a UK registry of 1,917 people with familial adenomatous polyposis, relatives identified through family screening had mortality comparable to the general population (median SMR 0.66), while those presenting with symptoms had a median SMR of 11.09.
- Author: Daniel Ryan
- Tags: Healthcare today, Cancer, United Kingdom, #peer-reviewed, #refines, #item, #source-2026-09

A UK registry cohort of 1,917 patients with familial adenomatous polyposis born after 1935 was compared with matched national mortality, with 364 deaths observed against 28 expected. Relatives detected through family screening had a median standardised mortality ratio of 0.66, whereas patients presenting newly with symptoms had a median of 11.09\. Colorectal disease fell from 64% of deaths before 2001 to 31% after 2013, while duodenal (3% to 12%) and gastric (1% to 8%) deaths rose.

*Why it is interesting: In a rare inherited cancer syndrome, relatives found through cascade screening show no excess mortality, and the remaining deaths have shifted towards upper gastrointestinal sites.*

Source

[American Journal of Gastroenterology, 18 September 2026](https://doi.org/10.14309/ajg.0000000000004205?ref=coios.me)

DOI

10.14309/ajg.0000000000004205

Type

Peer-reviewed article

Design

Retrospective life-table and cause-of-death analysis of a prospective FAP registry, 1917 patients born after 1935, 364 deaths

Verdict

Refines prior evidence

Driver

[Cancer](https://www.coios.me/d-cancer/)