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# Favourable lifestyle halved kidney stone incidence in 300,875 UK Biobank adults
- URL: https://www.coios.me/favourable-lifestyle-halved-kidney-stone-incidence-in-300/
- Published: 2026-09-20T09:39:30.000Z
- Updated: 2026-09-20T09:39:30.000Z
- Description: Among 300,875 UK Biobank participants followed a median 12.3 years, 3,088 developed kidney stones, and those scoring favourably on seven lifestyle items had a hazard ratio of 0.51 (0.44 to 0.59) against the unfavourable group.
- Author: Daniel Ryan
- Tags: Power of data, What linked data reveals, Diet and physical activity, United Kingdom, #peer-reviewed, #confirms, #item, #source-2026-09

A prospective analysis of 300,875 UK Biobank participants free of kidney stone disease scored seven lifestyle items - physical activity, body mass index below 25, sedentary time, sleep, smoking, fluid intake and diet - and followed them a median of 12.3 years, identifying 3,088 incident cases. The favourable group had a hazard ratio of 0.51 (0.44 to 0.59) against the unfavourable group. Unfavourable lifestyle combined with high polygenic risk gave 3.08 (2.49 to 3.80) against favourable lifestyle with low genetic risk, an additive rather than multiplicative interaction.

*Why it is interesting: The estimate is for the composite score, so diet and activity cannot be separated from the five other items it contains.*

Source

[Mayo Clinic Proceedings, 18 September 2026](https://doi.org/10.1016/j.mayocp.2026.08.023?ref=coios.me)

DOI

10.1016/j.mayocp.2026.08.023

Type

Peer-reviewed article

Design

Prospective cohort, UK Biobank, n=300,875, recruited 2006-2010, median 12.3 years' follow-up, 3,088 incident cases

Verdict

Confirms prior evidence

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)

Driver

[Diet and physical activity](https://www.coios.me/d-diet-activity/)