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# Gene-burden testing adds IMPA2 to dementia risk genes and ANKRD27 to Parkinson's
- URL: https://www.coios.me/gene-burden-testing-adds-impa2-to-dementia-risk-genes-and/
- Published: 2026-09-20T09:49:26.000Z
- Updated: 2026-09-20T09:49:26.000Z
- Description: A population-scale gene-burden analysis of rare damaging coding variants recovered eight established dementia genes including TREM2, SORL1 and GRN, and reported new associations at IMPA2 for dementia and at ANKRD27 and CCL7 for Parkinson's, in a preprint that is not yet peer reviewed.
- Author: Daniel Ryan
- Tags: Healthcare today, Dementia, #preprint, #new, #item, #source-2026-09

The authors tested the burden of rare loss-of-function and deleterious missense variants gene by gene across biobank and disease-focused sequencing cohorts, using calibrated proxy phenotypes to gain power for late-onset disease. At study-wide significance they recovered eight established dementia genes and two Parkinson's genes, and reported one new dementia association and two new Parkinson's associations. The strongest new signal, ANKRD27, showed damaging variants clustering in the domains that mediate Rab GTPase and retromer interactions; the sample size is not stated in the abstract.

*Why it is interesting: Rare-variant architecture bears on who develops dementia and on which pathways can be acted on, though an unreplicated preprint signal moves little on its own.*

Source

[medRxiv, 18 September 2026](https://doi.org/10.64898/2026.03.03.26347540?ref=coios.me)

DOI

10.64898/2026.03.03.26347540

Type

Preprint

Design

Gene-burden association testing of rare loss-of-function and deleterious missense variants in biobank and disease-focused sequencing cohorts, using proxy phenotypes; sample size not stated

Verdict

New finding

Driver

[Dementia](https://www.coios.me/d-dementia/)