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# Genome-wide study of 1,255 child and parental traits in 80,639 Japanese children
- URL: https://www.coios.me/genome-wide-study-of-1-255-child-and-parental-traits-in-80/
- Published: 2026-11-08T13:02:44.000Z
- Updated: 2026-11-08T14:11:45.000Z
- Description: Genotyping of 80,639 Japanese children found 6,073 loci across 1,255 traits, 18-20% of them new associations.
- Author: Daniel Ryan
- Tags: Data, models and systems, What linked data reveals, Revisions and new sources, Japan, #preprint, #new, #item, #source-2026-11, #score-62

Researchers ran genome-wide association studies in 80,639 children from the Japan Environment and Children's Study birth cohort. Cord blood genotypes were analysed with questionnaires and measurements collected from pregnancy to age 4\. Across 1,255 child and parental exposure traits, they found 6,073 common loci, about 18-20% of them new associations. Of these, 2,332 met a stricter significance threshold set to allow for testing so many traits. A longitudinal GWAS of BMI found 158 independent loci, 41 of which separate analyses at each age missed. Measures of child health and development cover only the first 4 years of life.

*Why it is interesting: Genetic data are paired with repeated measures from pregnancy through early childhood in one nationwide cohort. The longitudinal BMI analysis found loci that separate analyses at each age did not.*

Source

[medRxiv, 3 November 2026](https://doi.org/10.1101/2025.02.18.25322458?ref=coios.me)

Paper

Genome-wide association study on longitudinal and cross-sectional traits of child health and development in a Japanese population

Authors

Kumasaka N, Mezawa H, Naito T, Sakamoto K, Akiba K, Hattori A et al.

DOI

10.1101/2025.02.18.25322458

Type

Preprint

Design

Genome-wide association analysis in a nationwide prospective birth cohort (JECS), 80,639 genotyped children followed from pregnancy to age 4, 1,255 traits

Verdict

New finding

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)

Driver

[Revisions and new sources](https://www.coios.me/d-data-sources/)