> ## Content Index
> Fetch the complete content index at: https://www.coios.me/llms.txt
> Use this file to discover other available public pages before exploring further.

# GLP-1 receptor agonists and lower heart failure admission or death in diabetic HFrEF
- URL: https://www.coios.me/glp-1-receptor-agonists-and-lower-heart-failure-admission/
- Published: 2026-11-08T12:58:41.000Z
- Updated: 2026-11-08T14:12:41.000Z
- Description: In diabetic HFrEF, GLP-1 RA use had a 12-month risk ratio of 0.58 for heart failure admission or death.
- Author: Daniel Ryan
- Tags: Health today, Obesity, diabetes and GLP-1, #preprint, #refines, #item, #source-2026-11, #score-58

This retrospective cohort study identified 7,878 adults with diabetes and heart failure with reduced ejection fraction, 2014-2025\. The 793 who started a GLP-1 receptor agonist after heart failure diagnosis were exactly matched to 1,825 controls. The primary outcome was heart failure hospitalisation or death. Bootstrap risk ratios were 0.58 (95% CI 0.42-0.77) at 12 months and 0.72 (0.61-0.85) at 36 months. The number needed to treat was 17 at one year and 13 at three years, with consistent subgroup effects. Being observational, the study cannot exclude confounding by which patients were prescribed the drugs.

*Why it is interesting: It reports GLP-1 receptor agonist use alongside guideline-directed heart failure therapy in routine care. Because baseline event rates were high, the associated absolute difference in hospitalisation or death was large.*

Source

[medRxiv, 4 November 2026](https://doi.org/10.64898/2026.11.03.26367091?ref=coios.me)

Paper

Glucagon-like peptide-1 receptor agonists in diabetic patients with heart failure with reduced ejection fraction

Authors

Hammer Y, Cohen YJ, Arbel R, Razi T, Netzer D, Ben Gal T et al.

DOI

10.64898/2026.11.03.26367091

Type

Preprint

Design

Retrospective matched observational cohort, 7,878 adults with diabetes and HFrEF, 793 GLP-1 initiators vs 1,825 matched controls, 2014-2025, bootstrap risk ratios and Cox validation

Verdict

Refines prior evidence

Driver

[Obesity, diabetes and GLP-1](https://www.coios.me/d-obesity-diabetes/)