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# GLP-1 receptor agonists cut major cardiovascular events similarly below and above age 65
- URL: https://www.coios.me/glp-1-receptor-agonists-cut-major-cardiovascular-events/
- Published: 2026-10-31T11:14:00.000Z
- Updated: 2026-11-01T07:06:36.000Z
- Description: In eight trials, GLP-1 receptor agonists cut major cardiovascular events similarly above and below 65 (ratio of hazard ratios 1.03).
- Author: Daniel Ryan
- Tags: Health today, Obesity, diabetes and GLP-1, Heart and stroke, World, #peer-reviewed, #refines, #item, #source-2026-10, #score-62

This meta-analysis pooled eight randomised placebo-controlled trials of GLP-1 receptor agonists in 71,926 adults with type 2 diabetes or overweight/obesity. It tested whether effects on major adverse cardiovascular events (MACE: cardiovascular death, non-fatal myocardial infarction, non-fatal stroke) differ by age. Age-stratified hazard ratios were combined with random-effects models, and ratios of hazard ratios tested effect modification. Pooled hazard ratios were 0.81 (95% CI 0.69-0.94) under 65 and 0.84 (0.79-0.90) at 65 and over. The ratio of hazard ratios was 1.03 (0.85-1.25), with high between-trial heterogeneity (I2 59.3%). Only four trials reported a 75-and-over stratum, and that group was relatively small.

*Why it is interesting: It tests whether the trial reduction in cardiovascular deaths, heart attacks and strokes holds at older ages. Relative effects looked similar across age bands, though evidence above 75 rests on four trials and a small group.*

Source

[Diabetes, Obesity and Metabolism, 28 October 2026](https://doi.org/10.1111/dom.71496?ref=coios.me)

Paper

Cardiovascular Effects of GLP-1 Receptor Agonists Across Age Groups: An Updated Meta-Analysis of Randomized Controlled Trials

Authors

Fujii A, Hasebe M, Furuichi K, Yabe D, Yoshiji S

DOI

10.1111/dom.71496

Type

Peer-reviewed article

Design

Meta-analysis of 8 randomised placebo-controlled trials, 71,926 participants, age-stratified MACE, searched to July 2026

Verdict

Refines prior evidence

Driver

[Obesity, diabetes and GLP-1](https://www.coios.me/d-obesity-diabetes/)

Driver

[Heart and stroke](https://www.coios.me/d-cardiovascular/)

Free full text

[Free to read at the publisher](https://doi.org/10.1111/dom.71496?ref=coios.me)