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# Menopausal hormone therapy users had higher breast cancer incidence but lower mortality
- URL: https://www.coios.me/hormone-therapy-use-tracked-higher-breast-cancer-incidence/
- Published: 2026-10-10T08:08:14.000Z
- Updated: 2026-10-10T22:36:38.000Z
- Description: In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
- Author: Daniel Ryan
- Tags: Health today, Cancer, Slowing ageing itself, United States, #preprint, #new, #item, #source-2026-10

A secondary analysis of 78,209 women in the PLCO screening trial related menopause timing and hormone therapy use to breast cancer outcomes. Ever use of hormone therapy was associated with higher incidence (aHR 1.17), concentrated in hormone-receptor positive disease. Breast cancer mortality was lower in users (0.72), and later menopause was associated with slower ageing measured in blood DNA.

*Why it is interesting: Separates incidence from mortality for hormone therapy, and links earlier menopause to faster ageing measured in blood.*

Source

[medRxiv, 6 October 2026](https://doi.org/10.64898/2026.10.04.26364714?ref=coios.me)

Paper

Menopause timing, hormone therapy, epigenetic aging, and breast cancer outcomes: a secondary analysis of the PLCO Cancer Screening Trial

Authors

Zhai T, Pankratz VS, Zychowski KE, Li Y, Leslie KK, Guo Y et al.

DOI

10.64898/2026.10.04.26364714

Type

Preprint

Design

Secondary analysis of the PLCO screening trial cohort, 78,209 women, with a nested DNA methylation case-control subset (758 cases, 745 controls)

Verdict

New finding

Driver

[Cancer](https://www.coios.me/d-cancer/)

Driver

[Slowing ageing itself](https://www.coios.me/d-ageing/)