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# Immune gene HLA-DRB1*04 is commoner in centenarians, DRB1*01:01 in Alzheimer's patients
- URL: https://www.coios.me/immune-gene-hla-drb1-04-is-commoner-in-centenarians-drb1-01/
- Published: 2026-10-11T08:02:18.000Z
- Updated: 2026-10-11T09:14:53.000Z
- Description: Fine-mapping of HLA class II immune genes in 6,053 people found DRB1*04 subtypes commoner in 443 cognitively healthy centenarians, and DRB1*01:01 commoner in the 2,391 Alzheimer's patients.
- Author: Daniel Ryan
- Tags: Tomorrow's world, Slowing ageing itself, Dementia, What linked data reveals, Netherlands, #preprint, #refines, #item, #source-2026-10

Seven HLA class II haplotypes were fine-mapped in 443 cognitively healthy centenarians, 3,219 population controls and 2,391 Alzheimer's patients. A DRB1\*04 haplotype was commoner in centenarians and controls than in patients, and its link with lower tau pathology replicated in the Netherlands Brain Bank. DRB1\*01:01 was commoner in patients and rarer in centenarians, with less HLA class II carried on microglia in donated brain tissue.

*Why it is interesting: Immune genetics separate Alzheimer's risk from reaching 100 with intact cognition, and point beyond plaques and tangles.*

Source

[medRxiv, 9 October 2026](https://doi.org/10.64898/2026.08.24.26361177?ref=coios.me)

Paper

Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology

Authors

Alvarez Sirvent D, Luimes MC, Tesi N, Rohde SK, Salazar AN, Bijker LJ et al.

DOI

10.64898/2026.08.24.26361177

Type

Preprint

Design

Case-control fine-mapping of seven HLA-II haplotypes in 6,053 people (443 cognitively healthy centenarians, 3,219 controls, 2,391 Alzheimer's patients), with post-mortem replication in the Netherlands Brain Bank

Verdict

Refines prior evidence

Driver

[Slowing ageing itself](https://www.coios.me/d-ageing/)

Driver

[Dementia](https://www.coios.me/d-dementia/)

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)