> ## Content Index
> Fetch the complete content index at: https://www.coios.me/llms.txt
> Use this file to discover other available public pages before exploring further.

# Intrinsic capacity and disability and mortality risk in Japanese adults aged 85 to 89
- URL: https://www.coios.me/intrinsic-capacity-and-disability-and-mortality-risk-in/
- Published: 2026-11-08T13:16:11.000Z
- Updated: 2026-11-08T14:07:11.000Z
- Description: In two Japanese cohorts aged 85 to 89, higher intrinsic capacity was linked to lower risks of disability and death.
- Author: Daniel Ryan
- Tags: Health today, Frailty and multimorbidity, Slowing ageing itself, Japan, #peer-reviewed, #refines, #item, #source-2026-11, #score-76

KAWP (n = 942) and TOOTH (n = 393) are Japanese cohorts of community-dwelling adults aged 85 to 89\. Five intrinsic capacity domains formed a 0–100 score, tested separately in each cohort with adjusted Cox and Fine-Gray models. In KAWP, each 10-point higher score gave hazard ratios of 0.72 for care level 1 certification and 0.78 for death. In TOOTH, the ratios were 0.74 for death and 0.78 for dependency in daily activities or death. An exploratory cardio-renal measure, NT-proBNP with cystatin C, added modest but consistent information on death. The disability link was lost once death was a competing event, and the score is framed as a population-level marker.

*Why it is interesting: Evidence on intrinsic capacity is thin past age 85, where disability and death compete. The authors suggest the score captures shared vulnerability to both, as its disability link did not survive competing-risk analysis.*

Source

[The Journal of Frailty & Aging, 5 November 2026](https://doi.org/10.1016/j.tjfa.2026.100230?ref=coios.me)

Paper

Intrinsic capacity and risks of disability and mortality in octogenarians: a prospective analysis of two independent Japanese cohorts

Authors

Osawa Y, Sasaki T, Abe Y, Arai Y

DOI

10.1016/j.tjfa.2026.100230

Type

Peer-reviewed article

Design

Two independent prospective community cohorts of adults aged 85-89 in Japan (KAWP n=942; TOOTH n=393), Cox and Fine-Gray competing-risk models for incident disability and all-cause mortality

Verdict

Refines prior evidence

Driver

[Frailty and multimorbidity](https://www.coios.me/d-frailty-multimorbidity/)

Driver

[Slowing ageing itself](https://www.coios.me/d-ageing/)