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# Mobile PrEP and opioid treatment units did not raise uptake in people who inject drugs
- URL: https://www.coios.me/mobile-prep-and-opioid-treatment-units-did-not-raise-uptake/
- Published: 2026-11-08T13:08:48.000Z
- Updated: 2026-11-08T14:08:48.000Z
- Description: A mobile unit added to peer navigation did not raise PrEP or opioid medication use in 409 people injecting drugs.
- Author: Daniel Ryan
- Tags: Behavioural science, Alcohol and drug use, United States, #peer-reviewed, #new, #item, #source-2026-11, #score-68

This open-label randomised trial enrolled 409 HIV-negative adults with opioid use disorder who inject drugs, in five US cities. Both arms had 26 weeks of peer navigation; the intervention arm also had PrEP and buprenorphine on a mobile unit. At 26 weeks, biomarker-confirmed PrEP use was 5.4% vs 2.9%. Medication for opioid use disorder was 14.8% vs 10.7%; neither difference was significant. By 52 weeks, 4 intervention and 13 control participants had died (hazard ratio 0.29, 95% CI 0.1-0.9). The trial was not powered for mortality, and methadone was not available on the unit.

*Why it is interesting: Uptake of PrEP and opioid medication stayed low in both arms, even with peer support. The lower death count was a secondary finding that the authors say bears replication.*

Source

[JAMA Psychiatry, 4 November 2026](https://doi.org/10.1001/jamapsychiatry.2026.3644?ref=coios.me)

Paper

Mobile Units for Integrated Addiction and HIV Prevention Services for People Who Inject Drugs

Authors

Shoptaw S, El-Bassel N, Hanscom B, Skalland T, Denis C, Goodman-Meza D et al.

DOI

10.1001/jamapsychiatry.2026.3644

Full text

[Open copy](https://pmc.ncbi.nlm.nih.gov/articles/PMC13735193/?ref=coios.me) (open-access copy, PubMed Central)

Type

Peer-reviewed article

Design

Open-label two-arm randomised clinical trial, n=409 people who inject drugs, five US cities, May 2021–September 2024, 26- and 52-week outcomes

Verdict

New finding

Driver

[Alcohol and drug use](https://www.coios.me/d-alcohol-drugs/)