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# Multi-cancer blood test detected 15.4% of stage I cancers at 98.5% specificity
- URL: https://www.coios.me/multi-cancer-blood-test-detected-15-4-of-stage-i-cancers-at/
- Published: 2026-10-04T06:44:50.000Z
- Updated: 2026-10-04T07:34:50.000Z
- Description: A methylation and protein multi-cancer early detection blood test, assessed in a prospectively collected case-control study of 6,352 samples across 21 tumour types, had overall sensitivity of 50.9% at 98.5% specificity, rising from 15.4% at stage I to 85.5% at stage IV.
- Author: Daniel Ryan
- Tags: Healthcare today, Cancer, Innovation in treatment, #peer-reviewed, #confirms, #item, #source-2026-10

A methylation and protein classifier for multi-cancer early detection was evaluated on 6,352 samples (1,438 cancers, 4,914 non-cancers) spanning 21 tumour organ types and all stages, collected in a multi-centre prospective case-control study. At 98.5% specificity, overall sensitivity was 50.9%, rising from 15.4% at stage I to 85.5% at stage IV; excluding breast and prostate cancers, stage I sensitivity was 17.2%. An exploratory somatic mutation reflex step was examined for samples scoring between clear negative and positive thresholds.

*Why it is interesting: Sensitivity rises steeply with stage and stays below one in five at stage I, even with breast and prostate cancers excluded (17.2%).*

Source

[Cancer Epidemiology, Biomarkers & Prevention, 2 October 2026](https://doi.org/10.1158/1055-9965.epi-26-0541?ref=coios.me)

DOI

10.1158/1055-9965.epi-26-0541

Type

Peer-reviewed article

Design

Multi-centre prospectively collected case-control study, 6,352 samples (1,438 cancers, 21 organ types), split into training and test sets

Verdict

Confirms prior evidence

Driver

[Cancer](https://www.coios.me/d-cancer/)

Driver

[Innovation in treatment](https://www.coios.me/d-treatment-innovation/)