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# One in seven Danish anorexia patients follows a worsening severity course
- URL: https://www.coios.me/one-in-seven-danish-anorexia-patients-follows-a-worsening/
- Published: 2026-10-06T12:50:32.000Z
- Updated: 2026-10-06T17:11:33.000Z
- Description: In a Danish register cohort of 9,534 people with anorexia nervosa, 14% followed a high-increasing severity trajectory, which was associated with a higher anorexia polygenic score and with more psychiatric and somatic diagnoses in the five years after diagnosis.
- Author: Daniel Ryan
- Tags: Healthcare today, Obesity, diabetes and GLP-1, Mental health, What linked data reveals, Denmark, #preprint, #new, #item, #source-2026-10

A nationwide Danish register study derived a severity index for 9,534 people diagnosed with anorexia nervosa and modelled its course, with polygenic scores available for 5,126\. Three trajectories emerged, low and stable (32.6%), medium and stable (53.5%) and high increasing (14.0%), with each standard deviation of anorexia polygenic score corresponding to 13% greater odds of the high-increasing group. Pre-diagnosis psychiatric and somatic diagnoses did not distinguish the groups, while post-diagnosis morbidity did, with odds ratios of 1.73 to 3.81 for psychiatric and 1.61 to 5.38 for somatic conditions, and 0.27 for obesity.

*Why it is interesting: It separates the course of a high-mortality psychiatric disorder into distinct groups, and finds the morbidity divergence only after diagnosis rather than before it.*

Source

[medRxiv, 5 October 2026](https://doi.org/10.64898/2026.09.28.26364163?ref=coios.me)

DOI

10.64898/2026.09.28.26364163

Type

Preprint

Design

Population-based register cohort, Denmark, 9,534 people with anorexia nervosa born 1969-2013, genetic subsample 5,126

Verdict

New finding

Driver

[Obesity, diabetes and GLP-1](https://www.coios.me/d-obesity-diabetes/)

Driver

[Mental health](https://www.coios.me/d-mental-health/)

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)