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# Proteomic organ clocks tracked 16-year mortality slightly less than epigenetic age
- URL: https://www.coios.me/proteomic-organ-clocks-tracked-16-year-mortality-slightly/
- Published: 2026-10-03T13:05:12.000Z
- Updated: 2026-10-03T17:38:12.000Z
- Description: In the Lothian Birth Cohort 1936, accelerated liver, immune and heart proteomic ages were associated with 16-year mortality at hazard ratios of 1.38-1.43 per standard deviation, against 1.44-1.62 for GrimAge2, brain volume, respiratory function and cognition.
- Author: Daniel Ryan
- Tags: Tomorrow's world, Slowing ageing itself, Frailty and multimorbidity, United Kingdom, #peer-reviewed, #refines, #item, #source-2026-10

The study benchmarked plasma proteomic organ clocks against established ageing biomarkers for association with 16-year all-cause mortality in 861 members of the Lothian Birth Cohort 1936, among whom 444 died. Liver, immune and heart organ clocks carried hazard ratios of 1.38-1.43 per standard deviation, while epigenetic age, total brain and grey matter volume, respiratory function and cognition ranged from 1.44 to 1.62\. A separate survival analysis of 9703 protein targets identified 368 associated with mortality, led by GDF15 at 1.56 per standard deviation.

*Why it is interesting: A head-to-head comparison in one cohort sets the newer proteomic organ clocks against older epigenetic and functional measures for predicting death.*

Source

[Aging Cell, 1 October 2026](https://doi.org/10.1111/acel.70747?ref=coios.me)

DOI

10.1111/acel.70747

Type

Peer-reviewed article

Design

Prospective cohort, Lothian Birth Cohort 1936, 861 participants, 444 deaths over 16 years; Cox regression benchmarking of ageing biomarkers and 9703 plasma protein targets

Verdict

Refines prior evidence

Driver

[Slowing ageing itself](https://www.coios.me/d-ageing/)

Driver

[Frailty and multimorbidity](https://www.coios.me/d-frailty-multimorbidity/)