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# TAVR cut 2-year death or heart failure in moderate aortic stenosis with at-risk features
- URL: https://www.coios.me/tavr-cut-2-year-death-or-heart-failure-in-moderate-aortic/
- Published: 2026-11-07T13:18:59.000Z
- Updated: 2026-11-07T17:41:00.000Z
- Description: In moderate aortic stenosis with at-risk features, TAVR cut 2-year death or heart failure from 23.9% to 16.7%.
- Author: Daniel Ryan
- Tags: Health today, Heart and stroke, #peer-reviewed, #new, #item, #source-2026-11, #score-78

This international open-label trial randomised 744 patients with moderate aortic stenosis to TAVR or clinical surveillance. Each had at least one at-risk feature, a symptom or abnormality linked to faster progression or adverse outcomes. Mean age was 78 years, 39.1% were women, and TAVR used a transfemoral balloon-expandable valve. At 2 years, death or heart failure occurred in 16.7% with TAVR versus 23.9% with surveillance (difference -7.2 points). Heart-failure events were 10.8% versus 19.0%, and deaths from any cause 8.4% versus 7.3%. The main limitation is the open-label design, and the trial was funded by Edwards Lifesciences.

*Why it is interesting: Current guidelines recommend repeat heart scans every 1 or 2 years for moderate aortic stenosis, and this trial tests TAVR instead. Over 2 years the benefit came from fewer heart-failure events, not fewer deaths.*

Source

[New England Journal of Medicine, 2 November 2026](https://doi.org/10.1056/nejmoa2607326?ref=coios.me)

Paper

TAVR in Patients with Moderate Aortic Stenosis with At-Risk Features

Authors

Généreux P, Makkar RR, Pibarot P, Bax JJ, Lindman BR, Muhammad K et al.

DOI

10.1056/nejmoa2607326

Type

Peer-reviewed article

Design

International open-label randomised controlled trial, 744 patients with moderate aortic stenosis and at-risk features, 2-year follow-up (PROGRESS, NCT04889872), industry-funded

Verdict

New finding

Driver

[Heart and stroke](https://www.coios.me/d-cardiovascular/)