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# Top 10% by polygenic risk carry a fifth of Taiwan's atrial fibrillation
- URL: https://www.coios.me/top-10-by-polygenic-risk-carry-a-fifth-of-taiwan-s-atrial/
- Published: 2026-10-11T08:28:26.000Z
- Updated: 2026-10-11T09:10:26.000Z
- Description: Taiwan Biobank genotypes were linked to national insurance claims for 140,000 people, and those in the top 10% by polygenic risk were 3.56 times as likely to develop atrial fibrillation.
- Author: Daniel Ryan
- Tags: Health today, Heart and stroke, What linked data reveals, Taiwan, #preprint, #new, #item, #source-2026-10

The study linked Taiwan Biobank genotypes to National Health Insurance claims for 140,000 people, covering 42 non-communicable diseases. Those with the top-decile polygenic risk suffered a fifth of Taiwan's atrial fibrillation cases, and spent 24% more days in hospital.

*Why it is interesting: Earlier polygenic burden estimates were European; here the claims record also shows hospital use.*

Source

[medRxiv, 9 October 2026](https://doi.org/10.64898/2026.10.07.26365010?ref=coios.me)

Paper

Burden of Non-Communicable Diseases Attributable to Polygenic Risk and Its Association with Healthcare Utilization in Taiwan

Authors

Shih M, Ke Y, Chang X, Wang L, Feng YA

DOI

10.64898/2026.10.07.26365010

Type

Preprint

Design

Cohort linkage of Taiwan Biobank genotypes to National Health Insurance Research Database claims, n=140,000, 42 non-communicable diseases, Cox models with population attributable fractions and DALYs

Verdict

New finding

Driver

[Heart and stroke](https://www.coios.me/d-cardiovascular/)

Driver

[What linked data reveals](https://www.coios.me/d-linked-data/)