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# Weight loss after a prediabetes diagnosis tracked lower mortality 34 years later
- URL: https://www.coios.me/weight-loss-after-a-prediabetes-diagnosis-tracked-lower/
- Published: 2026-10-03T13:10:45.000Z
- Updated: 2026-10-03T17:29:45.000Z
- Description: In 540 Chinese adults with impaired glucose tolerance followed for 34 years, those losing at least 5% of body weight during the first six years had a hazard ratio of 0.67 for all-cause death and 0.56 for cardiovascular death compared with those who lost none.
- Author: Daniel Ryan
- Tags: Healthcare today, Heart and stroke, Obesity, diabetes and GLP-1, China, #peer-reviewed, #refines, #item, #source-2026-10

The Da Qing cohort of 540 adults with impaired glucose tolerance was split by weight change over the six-year lifestyle intervention and followed for 34 years. Participants losing 5% or more of baseline weight had hazard ratios of 0.67 for all-cause death, 0.56 for cardiovascular death and 0.48 for heart failure hospitalisation relative to those with no weight loss, although grouping by weight change after randomisation is a post hoc comparison. Median time to cardiovascular death was 6.5 years later in the high weight loss group.

*Why it is interesting: A 34-year follow-up of mortality by early weight change in people with impaired glucose tolerance.*

Source

[Diabetes Care, 1 October 2026](https://doi.org/10.2337/dc26-0689?ref=coios.me)

DOI

10.2337/dc26-0689

Type

Peer-reviewed article

Design

Post hoc analysis of the Da Qing Diabetes Prevention Study: 540 Chinese adults with impaired glucose tolerance grouped by weight change over the 6-year intervention, followed 34 years

Verdict

Refines prior evidence

Driver

[Heart and stroke](https://www.coios.me/d-cardiovascular/)

Driver

[Obesity, diabetes and GLP-1](https://www.coios.me/d-obesity-diabetes/)