Whether genomic risk prediction is good enough to use on whole populations

Polygenic score for osteoporosis shows modest discrimination gain in Japanese adults

A Japanese-ancestry polygenic score for ultrasound-defined osteoporosis added little to discrimination beyond age and sex, but quintile stratification gave incidence rate ratios of 1.42 in the lowest and 0.70 in the highest quintile over a mean 3.5 years of follow-up.