- 26 posts this week
- 21 drivers moved
- 3 trackers refreshed
- Releases this week
- 0 new on your watchlist
Official figures
Where the evidence stands
-
established strengtheningEnvironment: air, heat, cold
How air pollution, heat and cold affect how long people live, how the attribution is made, and how the balance is changing.
-
building mixedCancer
Which cancers are rising and which falling, what screening and new tests find earlier, what treatment has done to survival.
-
established mixedSocial connection
How isolation and loneliness shorten lives, proving the causal relationship and what can be done.
-
established mixedSmoking and vaping
How far smoking has fallen and how many deaths it still causes, what vaping is doing to the people who take it up, and what generational bans will show.
-
emerging mixedMedicine out of hospital
What wearables, remote monitoring and care at home add to how health is measured and delivered, and whether it shows in outcomes.
No papers yet -
building strengtheningObesity, diabetes and the GLP-1 drugs
Are obesity and diabetes still rising, understanding behavioural change and public policy, what difference do GLP-1 and friends make.
-
building strengtheningNew medicines
Which new drugs and vaccines could plausibly move how long people live, whether they reach the people who would benefit, and what the record says about medicines and life expectancy.
-
building strengtheningMigration and population change
How far fertility has fallen below what was projected, how migration has become the assumption that moves projections most, and what both do to the mortality statistics.
No papers yet -
building strengtheningWhat linked data reveals
What linked registries are making it possible to know about whole populations
-
building mixedMeasuring and projecting life expectancy
How the numbers are made, how much they revise their own past, and how well mortality can be forecast — and by whom.
No papers yet -
established steadyInfectious disease and pandemics
Infectious disease and pandemics: understanding both the risks and how well prepared we are
-
established strengtheningInequalities in health and length of life
Whether inequalities in health and length of life are widening, where, and what is happening to health at working ages.
-
building mixedFrailty and multimorbidity at the oldest ages
Whether the years added after 85 are healthy ones, how frailty and multiple conditions are measured, and where the limits of the data lie.
No papers yet -
established mixedDiet and physical activity
What people eat and how much they move, what the measured evidence says each does to how long they live, and what has been shown to change either.
No papers yet -
contested mixedDementia
Whether dementia is becoming more or less common, what is found earlier and why that clouds the count, what treatment and prevention now do, and what the deaths say.
No papers yet -
building mixedCardiovascular disease
Whether deaths from heart disease and stroke have stopped falling, what is found earlier, what treatment and prevention now do, and what the deaths say.
-
emerging strengtheningCapacity, funding and care
What waiting lists, workforce shortage and the slowing growth of health and care spending cost in lives & how societies are paying for and providing care for older people.
-
emerging strengtheningBiotechnology against inherited risk and ageing
What are the benefits of genomic risk prediction, what gene therapies can now do and at what cost, and whether anything yet slows ageing itself.
-
building strengtheningWhat changes behaviour at scale
What moves a population's behaviour — price, defaults, availability, incentives, information — and what the evidence on vaccination, screening and adherence says about which of them work.
-
established mixedAlcohol, drugs and suicide
What is happening to deaths from alcohol, drugs and suicide, whether they move together, and how much of it is behaviour and how much circumstance.
No papers yet -
emerging strengtheningAI in medicine
Whether machine learning predicts, detects and decides better than the tools we have, and whether that has yet changed an outcome for a population.
No papers yet
-
Item new peer-reviewed
An mRNA therapeutic vaccine clears HPV16 tumours in mice
An mRNA nanoparticle platform delivering HPV16 E6 and E7 antigens with IL-12 and LIGHT produced complete tumour regression and durable antigen-specific memory after intralesional injection in mouse models, with the same construct adapted to colorectal neoepitopes.
-
Item confirms peer-reviewed
Advanced CKD tracks higher in-hospital death in STEMI shock on circulatory support
In 63,755 weighted US hospitalisations for STEMI with cardiogenic shock treated with mechanical circulatory support, in-hospital mortality rose from 30.7% with no chronic kidney disease to 40.7% with stage 4–5 disease, an adjusted odds ratio of 1.26.
-
Item new peer-reviewed
No epidemiological evidence yet links e-cigarettes or snus to chemotherapy response
A systematic review of alternative tobacco and nicotine products during anticancer therapy found no epidemiological study of their effect on chemotherapy response, and a single in vitro signal of e-cigarette-induced cisplatin resistance failed to replicate in a multi-centre study.
-
Item confirms peer-reviewed
Review restates GLP-1 trial reductions in cardiovascular events and all-cause mortality
A narrative review in a Dutch cardiology journal restates the established trial evidence that GLP-1 receptor agonists reduce major adverse cardiovascular events, all-cause mortality and heart-failure hospitalisation in type 2 diabetes, with SELECT extending the effect to obesity without diabetes.
-
Item confirms peer-reviewed
Modelled estimates put 10.6m new cancers at 65+ in 2022, rising 75% by 2036
A secondary analysis of GLOBOCAN 2022 and GBD 2021 estimates reports 10.6 million new cancer cases and 6.0 million cancer deaths among adults aged 65 and over in 2022, with the modelled case count projected to rise 75.5% by 2036 as populations age.
-
Item confirms peer-reviewed
Asian Pacific Islanders had higher in-hospital death after heart attack than others in US
A propensity-matched analysis of US National Inpatient Sample admissions for acute myocardial infarction between 2003 and 2022 reports higher in-hospital mortality and more cardiac arrest, cardiogenic shock and stroke among Asian Pacific Islander patients than among others.
-
Item new peer-reviewed
Pharmacies gave 42% of first COVID vaccine doses to North Carolina children
Analysis of North Carolina's COVID-19 Vaccine Management System records for 1.75 million children aged 3-17 found pharmacies administered 42% of first doses, with an equal share in rural, suburban and urban areas but lower use among Black and Hispanic children.
-
Item new peer-reviewed
Pharmacies gave 42% of first COVID vaccine doses to North Carolina children
Analysis of North Carolina's COVID-19 Vaccine Management System records for 1.75 million children aged 3-17 found pharmacies administered 42% of first doses, with an equal share in rural, suburban and urban areas but lower use among Black and Hispanic children.
-
Item new peer-reviewed
GLP-1 users with obesity and asthma recorded fewer exacerbations than other weight drugs
In a propensity-matched TriNetX cohort of 4,846 adults with obesity and documented asthma, one-year recorded exacerbations were 1.7% with GLP-1-based therapy versus 4.0% with non-GLP weight-management drugs (risk ratio 0.44), with the authors ruling out causal inference.
-
Item confirms peer-reviewed
US paediatric firearm injury visits stayed above pre-pandemic levels through 2023
Across US children's hospitals, firearm-injury emergency visits in under-18s rose from 44.1 to 83.3 per month between 2016 and 2023, with the step change occurring in early 2020 and no significant trend since.
All items · Data watch · Revisions
Follow
Releases this week
Next seven days: ONS weekly deaths (Wed 16); Eurostat excess mortality (Wed 16); ONS monthly deaths (Thu 17); UKHSA all-cause mortality surveillance (Thu 17); CBS Eenzaamheid, in Dutch (Fri 18); Eurostat Healthcare personnel - dentists, pharmacists and physiotherapists (Fri 18); and 1 more. Full calendar