COIOS — COIOS - International risk research catalyst focused on health & longevity research
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Signal watch
Phrases whose share of new research papers rose sharply in the 14 days from 25 October to 7 November 2026, against the 102 days before. Each is shown with its driver and three of the papers using it.
Source: new papers indexed in PubMed and Europe PMC, on a driver's subject only. This list, for 25 October to 7 November 2026, comes from Europe PMC alone. A phrase is listed when it appears in at least eight papers from at least four journals, at three times or more its earlier share.
Official figures
Where the evidence stands
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Innovation in treatment
Treatments that did not exist before — drugs, operations, devices — and whether they reach the people who would benefit.
None this week Earlier → -
Diet, exercise and sleep
What people eat and how much they move: what the measured evidence says each does to mortality, and what has been shown to change either.
2 this week -
Forecasts and their record
How the forecasts are made, how well they explained the past, and how well mortality can be forecast — and by whom.
3 this week -
Cancer
Where is cancer incidence rising and falling, what screening and new tests find earlier, and what treatment has done to survival.
7 this week -
Obesity, diabetes and GLP-1
Are obesity and diabetes still rising, what behavioural change and public policy do, and what difference do GLP-1s and other similar drugs make.
4 this week -
Changing behaviour at scale
Whether new technology can change what people do at the scale of a population: apps, wearables, automated messages, digital programmes and platforms, and how far their effects last and reach.
None this week Earlier → -
Smoking and vaping
How far smoking has fallen and how many deaths it still causes, what vaping is doing to the people who take it up, and what generational bans will show.
None this week Earlier → -
What linked data reveals
What linked registries make it possible to know about whole populations
9 this week -
Alcohol and drug use
What is happening to deaths from alcohol, drugs and suicide, whether they move together, and how much of it is behaviour and how much circumstance.
4 this week -
Medicine at a distance
What wearables, remote monitoring and care at home add to how health is measured and delivered, and whether it shows in outcomes.
1 this week -
AI in medicine
Whether machine learning predicts, detects and decides better than the tools we have, and whether that has yet changed an outcome for a population.
4 this week -
Heart and stroke
Whether deaths from heart disease and stroke have stopped falling, what is found earlier, what treatment and prevention do now, and what the deaths say.
5 this week -
Mental health
Deaths by suicide, the life expectancy gap in severe mental illness, and the physical disease that follows it: what mental illness costs in lives.
3 this week -
Health systems and access
What the health system can provide and who gets it.
4 this week -
Social connection
Isolation, loneliness and mortality: what the evidence shows, how far the relationship is causal, and what interventions have shown.
1 this week -
A changing climate
How air pollution, heat and cold affect deaths and survival, how the attribution is made, and how the balance is changing.
4 this week -
Value in health
What a treatment, health programme or policy is worth against what it costs, and how far the models that decide it can be trusted.
3 this week -
Dementia
Whether dementia is becoming more or less common, what is now found, what treatment and prevention do, and what the deaths say.
3 this week -
Infection and pandemics
Infection and pandemics: the risks, and how well prepared we are
6 this week -
Slowing ageing itself
Whether anything yet slows ageing itself, rather than treating one disease at a time, and how we would know if it did.
2 this week -
Adherence and persistence
Whether a treatment is actually taken, for how long, and what changes either.
5 this week -
Revisions and new sources
What the figures are built from, what is newly available, and how much the numbers move when they are revised.
2 this week -
Frailty and multimorbidity
Whether the years added after 85 are healthy ones, how frailty and multiple conditions are measured, and where the data run out.
4 this week
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Tomorrow's worldA changing climate new
Global heat-related mortality rose by 29% in very strong El Niño years
Estimated heat-related mortality rose 29% in very strong El Niño years, most in low- and medium-Human Development Index regions.
Peer-reviewed -
Data, models and systemsAI in medicine refines
NEWS early warning score and machine learning give similar net benefit for 24 h mortality
A gradient-boosting model flagged at most 1·9 more 24 h deaths per 10 000 patients than NEWS, in Danish hospitals.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Intrinsic capacity and disability and mortality risk in Japanese adults aged 85 to 89
In two Japanese cohorts aged 85 to 89, higher intrinsic capacity was linked to lower risks of disability and death.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
US automotive plant closures were followed by more overdose deaths across drug classes
Automotive plant closures in 112 US counties were associated with 6.0 more overdose deaths per 100,000, across several drug classes.
Peer-reviewed -
Data, models and systemsHealth systems and access new
US health funding cuts in 2025 and HIV and TB service uptake in Kenya
After US health funding to Kenya stopped in early 2025, recorded HIV testing, prevention and treatment fell within two months.
Peer-reviewed -
Behavioural scienceSocial connection confirms
Loneliness is linked to higher mortality risk than social isolation in older Australians
Chronic loneliness had a mortality hazard ratio of 1.41 in Australians aged 50 and over, above social isolation's 1.19.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
Mobile PrEP and opioid treatment units did not raise uptake in people who inject drugs
A mobile unit added to peer navigation did not raise PrEP or opioid medication use in 409 people injecting drugs.
Peer-reviewed -
Health todayCancer refines
Real-world immune checkpoint inhibitor survival is often poorer than in pivotal trials
Of 2,514 Belgian metastatic patients on immune checkpoint inhibitors, 568 stopped without further therapy and survived a median 21.4 months.
Preprint · not peer-reviewed -
Health todayCancer refines
First-line covalent BTK inhibitors for CLL are often stopped early in US community care
Among 584 US community oncology patients with CLL/SLL, half had stopped first-line ibrutinib, acalabrutinib or zanubrutinib by 24 months, most often because of adverse events.
Peer-reviewed -
Tomorrow's worldA changing climate new
West Nile virus activity in Arizona linked to drought-monsoon cycles in modelling study
Models built on Arizona mosquito surveillance explained 65.3% of weekly variation in county-level human West Nile cases, one week ahead.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Vitamin D for US adults with prediabetes saved costs in a lifetime microsimulation model
In a simulated US cohort with prediabetes, daily vitamin D3 lowered lifetime costs by $3208 per person and added 0.12 QALYs, assuming the 15% cut in diabetes risk seen in pooled trials.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
COPD inhalers after British Columbia removed prior authorisation for first-line therapy
In 47,583 people with COPD, removing prior authorisation for LAMA preceded 0.8% more LAMA use and 1.3% less ICS/LABA use.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Genome-wide study of 1,255 child and parental traits in 80,639 Japanese children
Genotyping of 80,639 Japanese children found 6,073 loci across 1,255 traits, 18-20% of them new associations.
Preprint · not peer-reviewed -
Health todayCancer new
Early-onset colorectal tumours show more stromal cells and distinct gene expression
Colorectal tumours from younger adults held more stromal cells and expressed more long non-coding RNAs and epithelial-to-mesenchymal transition genes.
Peer-reviewed -
Data, models and systemsAI in medicine refines
Sybil deep learning model and biennial lung cancer screening in low-risk Lung-RADS scans
In 3,120 scans from one hospital, Sybil moved 33.8% of negative screens to biennial screening with no delayed cancers.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals new
Self-reported debt in UK survey data compared with credit reference agency records
Self-reported debt in a UK panel survey disagreed with credit reference records for some types, altering links with mental health.
Peer-reviewed -
Health todayCancer refines
Cancer mortality gap across Japanese prefectures moved north between 1995 and 2023
As cancer mortality fell, Japan's prefectural excess moved from liver cancer in the west to several cancers in the north.
Peer-reviewed -
Data, models and systemsForecasts and their record new
Women's health spending in poorer countries falls more steeply with debt service
In 71 poorer countries, each 1-point rise in debt service against GDP went with 4.2% lower women's health spending.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists and lower heart failure admission or death in diabetic HFrEF
In diabetic HFrEF, GLP-1 RA use had a 12-month risk ratio of 0.58 for heart failure admission or death.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Prompt Mental Health Care in Norway likely cost-effective versus usual care over 3 years
Prompt Mental Health Care cost €23,809 per QALY over 1 year and €6,376 over 3 years in a 738-person trial.
Peer-reviewed -
Health todayHeart and stroke new
TAVR cut 2-year death or heart failure in moderate aortic stenosis with at-risk features
In moderate aortic stenosis with at-risk features, TAVR cut 2-year death or heart failure from 23.9% to 16.7%.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Bariatric procedures linked to fewer diabetes complications and deaths than obesity drugs
Bariatric procedures were linked to lower 5-year nephropathy, retinopathy, cardiovascular events and deaths than obesity management medications.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Retinal deep learning biomarker estimates mortality risk and how it changes with age
RetiME, a deep learning model, maps retinal photographs to each person's mortality risk and how it changes with age.
Peer-reviewed -
Health todayHeart and stroke refines
LDL cholesterol after starting statins and cardiovascular events in primary prevention
In 185,237 statin starters, two-year LDL of 1.8-2.5 mmol/L carried a MACE hazard ratio of 0.80 against 2.6 or more.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Frailty prevalence in English adults aged 50 and over changed little from 2002 to 2022
Frailty in English adults aged 50 and over rose non-significantly from 15.5% to 17.8%, but the number with frailty grew from 2,560,122 to 3,791,038.
Peer-reviewed -
Health todayCancer refines
Surveillance mammography beyond 5 years and advanced second breast cancer in older women
In 9,888 older breast cancer survivors, continued mammography after 5 years was not linked to fewer advanced second primary cancers.
Peer-reviewed -
Data, models and systemsValue in health new
Opioid use disorder medication in residential treatment modelled for Massachusetts
A model found offering opioid use disorder medication in Massachusetts residential centres, with outpatient linkage, cost $40,195 per QALY gained.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Infector–infectee pairs in Dutch COVID-19 surveillance show who infected whom
In Dutch surveillance, 678,482 of 8 million COVID-19 cases named their most probable infector, giving a 3.6-day serial interval.
Preprint · not peer-reviewed -
Health todayDementia refines
Visual, hearing and dual sensory impairment linked to higher dementia risk in UK Biobank
Measured visual, hearing and dual sensory impairment each predicted dementia after allowing for baseline cognition, in 51,584 UK Biobank adults.
Peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Digital interventions for low back pain compared across 84 randomised trials
Virtual reality cut pain intensity most against control at the end of treatment, rated with moderate confidence.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
ICU admissions in Germany and atmospheric factors across eleven bioclimatic regions
Air pressure and heat were the atmospheric factors most often linked to German intensive care admissions over 15 years.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence new
Statin discontinuation in older adults and hospitalisation by frailty status in England
In English statin users aged 65 or older, stopping was linked to more hospital admissions, less so with greater frailty.
Peer-reviewed -
Health todayCancer refines
Cervical cancer cases and deaths worldwide in 2023, with forecasts to 2050
Worldwide, 887,000 new cervical cancer cases and 369,000 deaths were estimated for 2023, with rises forecast by 2050.
Peer-reviewed -
Health todayDementia refines
COVID-19 and later cognitive impairment and dementia by vaccination status in England
Dementia diagnoses rose sharply in the month after COVID-19, and cognitive impairment stayed raised for up to 4 years.
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
Statin intolerance is often followed by stopping all lipid-lowering therapy
In a US health system, 39.9% of patients with documented statin intolerance stopped all lipid-lowering therapy within 90 days.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Care management algorithms trained on past utilisation under-select disadvantaged adults
Among 201,216 US adults, utilisation-trained algorithms under-selected disadvantaged groups, and a health status target nearly closed the Black-White gap.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate new
Temperature-attributable deaths in South Korea split by avoidable and non-avoidable cause
Nearly one-third of temperature-attributable deaths in South Korea in 1990-2023 fell in preventable or treatable causes.
Peer-reviewed -
Health todayHeart and stroke refines
Oral anticoagulation after AF ablation raised bleeding without fewer ischaemic strokes
In 280,415 patients, continuing anticoagulation after AF ablation left ischaemic stroke unchanged but roughly tripled bleeding odds.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Vietnam theater veterans had higher accidental and lower intentional overdose death risk
Among 9,496,285 US Vietnam War-era veterans, those deployed to Vietnam had higher accidental and lower intentional overdose mortality.
Peer-reviewed -
Data, models and systemsHealth systems and access new
Centenarians in France had fewer acute hospital stays per head in 2023 than in 2014
Acute hospital stays among French centenarians fell from 53.2 to 45.4 per 100 between 2014 and 2023.
Peer-reviewed -
Data, models and systemsForecasts and their record refines
Stroke mortality in Japan showed a modest excess in 2022, concentrated in older men
Japan recorded 3,434 excess stroke deaths in 2020-2022, almost all in 2022 and mostly among males aged 70 or over.
Peer-reviewed -
Health todayDementia new
Physical frailty and faster clinical decline on lecanemab in early Alzheimer's disease
In 187 patients starting lecanemab, physical frailty was linked to faster decline on the CDR-SB and more infusion-related reactions.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
MIND diet adherence and later epigenetic ageing in the Health and Retirement Study
In 1,740 older US adults, higher 2013 MIND diet scores were associated with lower epigenetic ageing in 2016.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics refines
Excess mortality in South Korea peaked in 2022 and stayed raised through 2024
South Korea had 194,173 excess deaths (+12.8%) in 2020-2024, peaking in 2022 and still 18.3% above expected in 2024.
Peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Antidepressant persistence in Manitoba falls to 25% by one year after first prescription
Of 76,200 new antidepressant users with mood or anxiety disorders, 30.2% filled only once and 75.4% stopped within a year.
Peer-reviewed -
Health todayCancer refines
Oropharyngeal cancer incidence rising across Europe, with HPV behind 43% of cases
Registries reported 22,063 new oropharyngeal cancer cases in 29 European countries in 2024, 43.3% attributable to HPV.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Diagnosed diabetes in Korea rose with age and year, with higher odds in two birth cohorts
In 3.2 million Korean survey respondents, reported diagnosed diabetes rose with age and year and was higher in two cohorts.
Peer-reviewed -
Health todayMental health refines
Online mindfulness-based cognitive therapy and perinatal depressive relapse in the USA
In 500 pregnant women with recurrent depression, online mindfulness training cut relapse to 6 months postpartum from 44% to 33%.
Peer-reviewed -
Behavioural scienceDiet, exercise and sleep confirms
Weekend warrior and regularly active patterns show no clear difference in mortality
Weekend warriors had a pooled all-cause mortality hazard ratio of 1.019 against the regularly active, at very low certainty.
Peer-reviewed -
Data, models and systemsWhat linked data reveals confirms
Real spending on high-cost 'high-impact' medicines in Catalonia rose about 30%, 2019–2024
Nominal spending on high-impact medicines in Catalonia rose from €1.10 billion in 2019 to €1.69 billion in 2024.
Peer-reviewed -
Data, models and systemsValue in health refines
UK food tax designs modelled for effects on diet, health, NHS costs and inequality
Modelled UK food taxes cut 25 to 58 kcal a day; only the sugar and salt tax narrowed health inequalities.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Heatwave exposure of infants and older adults rose in Australia and New Zealand, 2016–2025
In 2021–2025, climate change accounted for 65% of heatwave days in Australia and 73% in New Zealand.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Transcatheter aortic valve implantation in Japan: care needs, costs and mortality
After TAVI, Japanese patients in the most dependent care group had about five times the costs and higher mortality.
Peer-reviewed -
Health todayCancer refines
Colorectal cancer PRS link wanes with onset age; additive gene-lifestyle interaction late
High versus low polygenic risk gave colorectal cancer hazard ratios of 3.72 before age 55 and 2.01 from 75.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Rural drug-related deaths in the UK show more self-poisoning and more prescribed drugs
About one in 11 UK drug-related deaths was rural, and rural deaths more often involved intentional self-poisoning (17.3% vs 9.5%).
Peer-reviewed -
Tomorrow's worldA changing climate refines
Indoor heat and mortality: a model mapping outdoor exposure-response curves indoors
Because indoor temperature rises less than outdoor temperature, a 1°C rise indoors may be linked to a larger mortality change than a 1°C rise outdoors.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Multimorbidity after myocardial infarction clusters into three trajectories in UK Biobank
In 12 701 UK Biobank participants after myocardial infarction, three multimorbidity trajectories emerged; the SMART score predicted mortality better.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
Semaglutide for obesity: two-thirds of new Wegovy users stopped within a year
Of 34,309 Clalit members without diabetes starting Wegovy in 2025, 67.6% had stopped by one year.
Peer-reviewed -
Data, models and systemsRevisions and new sources new
Electronic death certificates cut garbage codes in Norway's Cause of Death Registry
In Norwegian deaths, 2018-2023, electronic certificates were 21% less likely than paper ones to record a garbage code.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Heavy and high-intensity drinking among US adults fell in prevalence from 1984 to 2024
Fewer US adults drink heavily than in 1984, but heavy-drinking days rose among women and older adults after 2010.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Antimicrobial resistance deaths linked to human antibiotic use across 114 countries
In a modelled scenario, 10% less antibiotic use meant 38,000 fewer yearly antimicrobial resistance deaths, 0.50% of bacterial disease mortality.
Peer-reviewed -
Tomorrow's worldInnovation in treatment new
Individualised mRNA melanoma vaccine with pembrolizumab cuts recurrence or death by 42%
Adding intismeran autogene to pembrolizumab after melanoma was removed reduced recurrence or death risk by 42% in phase III INTerpath-0001.
Peer-reviewed -
Data, models and systemsValue in health confirms
Lecanemab and donanemab for early Alzheimer's disease are not cost-effective in China
A lifetime Markov model found that neither lecanemab nor donanemab was cost-effective at current Chinese prices, from either perspective.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Antimicrobial resistance in Chinese bloodstream infections over a decade, 2014 to 2023
Across 76,211 Chinese bloodstream isolates, ESBL-producing E. coli fell to 47.4% and carbapenem-resistant K. pneumoniae rose to 14.9%.
Peer-reviewed -
Health todayDementia refines
Cognition in healthy adults: modifiable risk factors linked to performance, not decline
Five modifiable dementia risk factors were linked to cognitive level, not decline, in 1,396 healthy adults aged 36 to 108.
Preprint · not peer-reviewed -
Health todayCancer refines
Breast cancer survival by stage across Europe after harmonising registry TNM data
Ten-year relative survival of European women with breast cancer was 97% at stage I and 10% at stage IV.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists' share of US prescriptions rose 7% from June to September 2026
Anti-obesity GLP-1 prescribing rose 12.2% in mid-2026, with the largest monthly rise in July, when a Medicare cost-cutting programme began.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine refines
AI-derived ECG features add little beyond automated ECG reports for 30-day mortality
Deep-learning ECG features beat simple morphology measurements for 30-day mortality, but added little over the ECG machine's own automated report.
Preprint · not peer-reviewed -
Health todayCancer refines
Interval colorectal cancer after negative FIT rises with faecal haemoglobin level
Faecal haemoglobin just below the 20 µg/g positive cut-off was associated with 15 times the interval cancer hazard of 0-5 µg/g.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Capivasertib with abiraterone: modelled $3,120,720 per QALY in PTEN-deficient mHSPC
In a US payer model, capivasertib plus abiraterone for PTEN-deficient mHSPC cost $3,120,720 per QALY gained.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Semaglutide for weight management and use of other prescribed medicines in Denmark
In 189,392 Danish semaglutide initiators, antiasthmatic use fell below trend (RR 0.82) while anxiolytic use rose (RR 1.16).
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Ontario measles outbreak of 2377 cases contributed to Canada losing elimination status
Ontario's 2377-case measles outbreak mainly affected unvaccinated young people; its strain was detected in the USA, Mexico and the Netherlands.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists versus other diabetes drugs across 181 outcomes in type 2 diabetes
Against other diabetes drugs, GLP-1 receptor agonists were linked to lower cardiovascular and renal risk but higher musculoskeletal risk.
Peer-reviewed -
Data, models and systemsValue in health refines
Hemgenix for haemophilia B costs more than factor IX prophylaxis over the first ten years
In a Swedish budget-impact model, Hemgenix cost more than factor IX prophylaxis over 10 years under every payment model.
Peer-reviewed -
Data, models and systemsAI in medicine new
SPARC transformer model uses routine measurements to predict cancer adverse events
A transformer model trained on 224,047 patients' routine measurements predicted cancer adverse events in prospective and external cohorts.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence refines
SGLT-2 inhibitors show higher adherence and persistence than GLP-1 RAs in type 2 diabetes
SGLT-2 inhibitors had higher adherence and persistence than GLP-1 receptor agonists in 14,998 matched patients, most clearly with cardiovascular disease.
Peer-reviewed -
Health todayMental health refines
Borderline personality disorder linked to near six-fold all-cause mortality in New Zealand
In 10,059 New Zealanders with borderline personality disorder, all-cause mortality was 5.8 times the general population rate.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Influenza hospitalisation gaps by ethnic group in England partly run through deprivation
In England's 2023–24 vaccine-eligible cohort, deprivation mediated 26% of excess influenza hospitalisation odds in Pakistani and 41% in Bangladeshi groups.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Weather and child hospitalisation in Sweden: heat, intraday temperature swings and rain
Among 4,638,247 Swedish children, heat, very low or very high intraday temperature swings and more rain were linked to admissions.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Smoking-persistence polygenic score linked to an 8-year gap in median quitting age
Top-decile smokers on a smoking-persistence polygenic score quit at an adjusted median age 8 years older than bottom-decile smokers.
Preprint · not peer-reviewed -
Behavioural scienceSocial connection refines
Living alone and mortality in older Koreans: link lost after socioeconomic weighting
Among 3,771 older Koreans, living alone was linked to higher mortality, but not after weighting for income, education and area.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Dementia and emergency hospital use before and after diagnosis in North West London
Before dementia diagnosis, emergency admission rates were 5.35 times those of residents without dementia, rising to 6.67 times after diagnosis.
Preprint · not peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
GrimAge epigenetic clock predicts survival in Dutch centenarians beyond cognition
Among 247 Dutch centenarians, higher GrimAge acceleration predicted higher mortality independently of cognition; adding MMSE improved survival stratification.
Preprint · not peer-reviewed -
Health todayCancer refines
Colorectal cancer incidence in the US rose in 2023 after two decades of decline
US colorectal cancer incidence fell from 55.2 per 100,000 in 2000 to 36.7 in 2022, rising to 38.3 in 2023.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists cut major cardiovascular events similarly below and above age 65
In eight trials, GLP-1 receptor agonists cut major cardiovascular events similarly above and below 65 (ratio of hazard ratios 1.03).
Peer-reviewed -
Health todayCancer refines
Mental health disorders and breast and bowel cancer screening and stage in Taiwan
In Taiwan, people with mental health disorders screened slightly more for breast and bowel cancer; severe cases screened less.
Peer-reviewed -
Health todayCancer refines
Lung adenocarcinoma across the COVID-19 era: small stage shifts, longer treatment delays
Lung adenocarcinoma stage barely shifted across the COVID-19 era, but treatment delays over 90 days rose from 10.2% to 14.5%.
Peer-reviewed -
Health todayHeart and stroke new
Anticoagulation discontinuation in long-term care residents with atrial fibrillation
In 15,426 US long-term care residents with atrial fibrillation, stopping anticoagulation was not linked to more strokes or bleeds.
Peer-reviewed -
Health todayMental health refines
Psychiatric in-patients follow two trajectories with similarly high mortality
In one NHS psychiatry service, severe enduring illness used most beds, crisis stays were brief, but adjusted mortality was similar.
Peer-reviewed -
Health todayCancer refines
Obesity in Korean adults aged 20 to 39 and risk of early-onset cancer into midlife
Ten-year cancer incidence among young Korean adults was 1.84% at normal weight and 2.62% in class II obesity.
Peer-reviewed -
Health todayCancer new
Cancer risk in first-generation migrants varies by birth country and cancer site in Europe
In European migrants, cervical, stomach and liver cancer risk rose with birth-country incidence; breast and colorectal risk was lower.
Preprint · not peer-reviewed -
Behavioural scienceAlcohol and drug use new
Stimulant toxicity emergency visits followed by 2.1% one-year mortality, mostly overdose
Of 2,356 patients discharged after emergency visits for stimulant toxicity, 2.1% died within a year, two-thirds from overdose.
Peer-reviewed -
Behavioural scienceInfection and pandemics confirms
H5N1 avian influenza in US dairy herds clusters where non-waterfowl birds are abundant
Early US dairy H5N1 outbreaks sat in counties with more non-waterfowl birds than high-cattle-density counties without outbreaks.
Preprint · not peer-reviewed -
Data, models and systemsValue in health confirms
Lecanemab for early Alzheimer's disease in China exceeds the cost-effectiveness threshold
Lecanemab added 1.24 QALYs in early Alzheimer's disease in China, but cost 372,609 yuan per QALY, above the threshold.
Peer-reviewed -
Health todayCancer new
Off-label oncology drug use spans over a third of reimbursable Dutch drug–cancer pairings
In 2023 a quarter of Dutch high-cost cancer drug prescriptions were off-label, but they made up 2.3% of spending.
Peer-reviewed -
Health todayMental health new
Educational gap for young people using child mental health services in Wales widened
Young people using child mental health services in Wales fell further behind peers in basic GCSE passes over time.
Peer-reviewed -
Health todayHeart and stroke new
Home blood pressure monitoring in US veterans and later deaths and cardiovascular events
In 30,203 veterans using home blood pressure monitoring and 30,096 matched controls, monitoring was linked to 8% lower all-cause mortality.
Preprint · not peer-reviewed -
Health todayDementia refines
Eating difficulty marks functional vulnerability rather than triggering cognitive decline
In four ageing cohorts, new eating difficulty was associated with higher dementia-indicator risk, but tooth loss showed little adjusted association.
Peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch use in US youth: flavours and convenience linked to more frequent use
US youth who tried nicotine pouches mostly cited experimentation, but flavours, convenience and feeling addicted were tied to frequent use.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Respiratory infection hospitalisation risk in New Zealand predicted by gradient boosting
Gradient boosting models using demographics, morbidity indices and influenza vaccination status separated people with and without a respiratory infection hospitalisation, across about 5 million New Zealanders each year.
Preprint · not peer-reviewed
-
Health todayFrailty and multimorbidity refines
Intrinsic capacity and disability and mortality risk in Japanese adults aged 85 to 89
In two Japanese cohorts aged 85 to 89, higher intrinsic capacity was linked to lower risks of disability and death.
Peer-reviewed -
Health todayCancer refines
Real-world immune checkpoint inhibitor survival is often poorer than in pivotal trials
Of 2,514 Belgian metastatic patients on immune checkpoint inhibitors, 568 stopped without further therapy and survived a median 21.4 months.
Preprint · not peer-reviewed -
Health todayCancer refines
First-line covalent BTK inhibitors for CLL are often stopped early in US community care
Among 584 US community oncology patients with CLL/SLL, half had stopped first-line ibrutinib, acalabrutinib or zanubrutinib by 24 months, most often because of adverse events.
Peer-reviewed -
Health todayCancer new
Early-onset colorectal tumours show more stromal cells and distinct gene expression
Colorectal tumours from younger adults held more stromal cells and expressed more long non-coding RNAs and epithelial-to-mesenchymal transition genes.
Peer-reviewed -
Health todayCancer refines
Cancer mortality gap across Japanese prefectures moved north between 1995 and 2023
As cancer mortality fell, Japan's prefectural excess moved from liver cancer in the west to several cancers in the north.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists and lower heart failure admission or death in diabetic HFrEF
In diabetic HFrEF, GLP-1 RA use had a 12-month risk ratio of 0.58 for heart failure admission or death.
Preprint · not peer-reviewed -
Health todayHeart and stroke new
TAVR cut 2-year death or heart failure in moderate aortic stenosis with at-risk features
In moderate aortic stenosis with at-risk features, TAVR cut 2-year death or heart failure from 23.9% to 16.7%.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Bariatric procedures linked to fewer diabetes complications and deaths than obesity drugs
Bariatric procedures were linked to lower 5-year nephropathy, retinopathy, cardiovascular events and deaths than obesity management medications.
Peer-reviewed -
Health todayHeart and stroke refines
LDL cholesterol after starting statins and cardiovascular events in primary prevention
In 185,237 statin starters, two-year LDL of 1.8-2.5 mmol/L carried a MACE hazard ratio of 0.80 against 2.6 or more.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Frailty prevalence in English adults aged 50 and over changed little from 2002 to 2022
Frailty in English adults aged 50 and over rose non-significantly from 15.5% to 17.8%, but the number with frailty grew from 2,560,122 to 3,791,038.
Peer-reviewed -
Health todayCancer refines
Surveillance mammography beyond 5 years and advanced second breast cancer in older women
In 9,888 older breast cancer survivors, continued mammography after 5 years was not linked to fewer advanced second primary cancers.
Peer-reviewed -
Health todayDementia refines
Visual, hearing and dual sensory impairment linked to higher dementia risk in UK Biobank
Measured visual, hearing and dual sensory impairment each predicted dementia after allowing for baseline cognition, in 51,584 UK Biobank adults.
Peer-reviewed -
Health todayCancer refines
Cervical cancer cases and deaths worldwide in 2023, with forecasts to 2050
Worldwide, 887,000 new cervical cancer cases and 369,000 deaths were estimated for 2023, with rises forecast by 2050.
Peer-reviewed -
Health todayDementia refines
COVID-19 and later cognitive impairment and dementia by vaccination status in England
Dementia diagnoses rose sharply in the month after COVID-19, and cognitive impairment stayed raised for up to 4 years.
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
Statin intolerance is often followed by stopping all lipid-lowering therapy
In a US health system, 39.9% of patients with documented statin intolerance stopped all lipid-lowering therapy within 90 days.
Peer-reviewed -
Health todayHeart and stroke refines
Oral anticoagulation after AF ablation raised bleeding without fewer ischaemic strokes
In 280,415 patients, continuing anticoagulation after AF ablation left ischaemic stroke unchanged but roughly tripled bleeding odds.
Peer-reviewed -
Health todayDementia new
Physical frailty and faster clinical decline on lecanemab in early Alzheimer's disease
In 187 patients starting lecanemab, physical frailty was linked to faster decline on the CDR-SB and more infusion-related reactions.
Peer-reviewed -
Health todayCancer refines
Oropharyngeal cancer incidence rising across Europe, with HPV behind 43% of cases
Registries reported 22,063 new oropharyngeal cancer cases in 29 European countries in 2024, 43.3% attributable to HPV.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Diagnosed diabetes in Korea rose with age and year, with higher odds in two birth cohorts
In 3.2 million Korean survey respondents, reported diagnosed diabetes rose with age and year and was higher in two cohorts.
Peer-reviewed -
Health todayMental health refines
Online mindfulness-based cognitive therapy and perinatal depressive relapse in the USA
In 500 pregnant women with recurrent depression, online mindfulness training cut relapse to 6 months postpartum from 44% to 33%.
Peer-reviewed -
Health todayCancer refines
Colorectal cancer PRS link wanes with onset age; additive gene-lifestyle interaction late
High versus low polygenic risk gave colorectal cancer hazard ratios of 3.72 before age 55 and 2.01 from 75.
Peer-reviewed -
Health todayDementia refines
Cognition in healthy adults: modifiable risk factors linked to performance, not decline
Five modifiable dementia risk factors were linked to cognitive level, not decline, in 1,396 healthy adults aged 36 to 108.
Preprint · not peer-reviewed -
Health todayCancer refines
Breast cancer survival by stage across Europe after harmonising registry TNM data
Ten-year relative survival of European women with breast cancer was 97% at stage I and 10% at stage IV.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists' share of US prescriptions rose 7% from June to September 2026
Anti-obesity GLP-1 prescribing rose 12.2% in mid-2026, with the largest monthly rise in July, when a Medicare cost-cutting programme began.
Preprint · not peer-reviewed -
Health todayCancer refines
Interval colorectal cancer after negative FIT rises with faecal haemoglobin level
Faecal haemoglobin just below the 20 µg/g positive cut-off was associated with 15 times the interval cancer hazard of 0-5 µg/g.
Preprint · not peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Semaglutide for weight management and use of other prescribed medicines in Denmark
In 189,392 Danish semaglutide initiators, antiasthmatic use fell below trend (RR 0.82) while anxiolytic use rose (RR 1.16).
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists versus other diabetes drugs across 181 outcomes in type 2 diabetes
Against other diabetes drugs, GLP-1 receptor agonists were linked to lower cardiovascular and renal risk but higher musculoskeletal risk.
Peer-reviewed -
Health todayMental health refines
Borderline personality disorder linked to near six-fold all-cause mortality in New Zealand
In 10,059 New Zealanders with borderline personality disorder, all-cause mortality was 5.8 times the general population rate.
Peer-reviewed -
Health todayCancer refines
Colorectal cancer incidence in the US rose in 2023 after two decades of decline
US colorectal cancer incidence fell from 55.2 per 100,000 in 2000 to 36.7 in 2022, rising to 38.3 in 2023.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists cut major cardiovascular events similarly below and above age 65
In eight trials, GLP-1 receptor agonists cut major cardiovascular events similarly above and below 65 (ratio of hazard ratios 1.03).
Peer-reviewed -
Health todayCancer refines
Mental health disorders and breast and bowel cancer screening and stage in Taiwan
In Taiwan, people with mental health disorders screened slightly more for breast and bowel cancer; severe cases screened less.
Peer-reviewed -
Health todayCancer refines
Lung adenocarcinoma across the COVID-19 era: small stage shifts, longer treatment delays
Lung adenocarcinoma stage barely shifted across the COVID-19 era, but treatment delays over 90 days rose from 10.2% to 14.5%.
Peer-reviewed -
Health todayHeart and stroke new
Anticoagulation discontinuation in long-term care residents with atrial fibrillation
In 15,426 US long-term care residents with atrial fibrillation, stopping anticoagulation was not linked to more strokes or bleeds.
Peer-reviewed -
Health todayMental health refines
Psychiatric in-patients follow two trajectories with similarly high mortality
In one NHS psychiatry service, severe enduring illness used most beds, crisis stays were brief, but adjusted mortality was similar.
Peer-reviewed -
Health todayCancer refines
Obesity in Korean adults aged 20 to 39 and risk of early-onset cancer into midlife
Ten-year cancer incidence among young Korean adults was 1.84% at normal weight and 2.62% in class II obesity.
Peer-reviewed -
Health todayCancer new
Cancer risk in first-generation migrants varies by birth country and cancer site in Europe
In European migrants, cervical, stomach and liver cancer risk rose with birth-country incidence; breast and colorectal risk was lower.
Preprint · not peer-reviewed -
Health todayCancer new
Off-label oncology drug use spans over a third of reimbursable Dutch drug–cancer pairings
In 2023 a quarter of Dutch high-cost cancer drug prescriptions were off-label, but they made up 2.3% of spending.
Peer-reviewed -
Health todayMental health new
Educational gap for young people using child mental health services in Wales widened
Young people using child mental health services in Wales fell further behind peers in basic GCSE passes over time.
Peer-reviewed -
Health todayHeart and stroke new
Home blood pressure monitoring in US veterans and later deaths and cardiovascular events
In 30,203 veterans using home blood pressure monitoring and 30,096 matched controls, monitoring was linked to 8% lower all-cause mortality.
Preprint · not peer-reviewed -
Health todayDementia refines
Eating difficulty marks functional vulnerability rather than triggering cognitive decline
In four ageing cohorts, new eating difficulty was associated with higher dementia-indicator risk, but tooth loss showed little adjusted association.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 RA use and neuropsychiatric outcomes in Medicare enrolees with type 2 diabetes
GLP-1 RA users had more depression (HR 1.11) but fewer substance use disorders, dementia and suicidal or self-harm events.
Peer-reviewed -
Health todayMental health refines
Suicide mortality in the Americas rose from 2015 to 2021 despite a one-third cut target
The regional age-standardised suicide mortality rate rose by 1·05% a year on average between 2015 and 2021, and only 10 of 33 countries fell fast enough to meet a one-third cut by 2030.
Peer-reviewed
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Behavioural scienceAlcohol and drug use refines
US automotive plant closures were followed by more overdose deaths across drug classes
Automotive plant closures in 112 US counties were associated with 6.0 more overdose deaths per 100,000, across several drug classes.
Peer-reviewed -
Behavioural scienceSocial connection confirms
Loneliness is linked to higher mortality risk than social isolation in older Australians
Chronic loneliness had a mortality hazard ratio of 1.41 in Australians aged 50 and over, above social isolation's 1.19.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
Mobile PrEP and opioid treatment units did not raise uptake in people who inject drugs
A mobile unit added to peer navigation did not raise PrEP or opioid medication use in 409 people injecting drugs.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
COPD inhalers after British Columbia removed prior authorisation for first-line therapy
In 47,583 people with COPD, removing prior authorisation for LAMA preceded 0.8% more LAMA use and 1.3% less ICS/LABA use.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Infector–infectee pairs in Dutch COVID-19 surveillance show who infected whom
In Dutch surveillance, 678,482 of 8 million COVID-19 cases named their most probable infector, giving a 3.6-day serial interval.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence new
Statin discontinuation in older adults and hospitalisation by frailty status in England
In English statin users aged 65 or older, stopping was linked to more hospital admissions, less so with greater frailty.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Vietnam theater veterans had higher accidental and lower intentional overdose death risk
Among 9,496,285 US Vietnam War-era veterans, those deployed to Vietnam had higher accidental and lower intentional overdose mortality.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Excess mortality in South Korea peaked in 2022 and stayed raised through 2024
South Korea had 194,173 excess deaths (+12.8%) in 2020-2024, peaking in 2022 and still 18.3% above expected in 2024.
Peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Antidepressant persistence in Manitoba falls to 25% by one year after first prescription
Of 76,200 new antidepressant users with mood or anxiety disorders, 30.2% filled only once and 75.4% stopped within a year.
Peer-reviewed -
Behavioural scienceDiet, exercise and sleep confirms
Weekend warrior and regularly active patterns show no clear difference in mortality
Weekend warriors had a pooled all-cause mortality hazard ratio of 1.019 against the regularly active, at very low certainty.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Rural drug-related deaths in the UK show more self-poisoning and more prescribed drugs
About one in 11 UK drug-related deaths was rural, and rural deaths more often involved intentional self-poisoning (17.3% vs 9.5%).
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
Semaglutide for obesity: two-thirds of new Wegovy users stopped within a year
Of 34,309 Clalit members without diabetes starting Wegovy in 2025, 67.6% had stopped by one year.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Heavy and high-intensity drinking among US adults fell in prevalence from 1984 to 2024
Fewer US adults drink heavily than in 1984, but heavy-drinking days rose among women and older adults after 2010.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Antimicrobial resistance deaths linked to human antibiotic use across 114 countries
In a modelled scenario, 10% less antibiotic use meant 38,000 fewer yearly antimicrobial resistance deaths, 0.50% of bacterial disease mortality.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Antimicrobial resistance in Chinese bloodstream infections over a decade, 2014 to 2023
Across 76,211 Chinese bloodstream isolates, ESBL-producing E. coli fell to 47.4% and carbapenem-resistant K. pneumoniae rose to 14.9%.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Ontario measles outbreak of 2377 cases contributed to Canada losing elimination status
Ontario's 2377-case measles outbreak mainly affected unvaccinated young people; its strain was detected in the USA, Mexico and the Netherlands.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
SGLT-2 inhibitors show higher adherence and persistence than GLP-1 RAs in type 2 diabetes
SGLT-2 inhibitors had higher adherence and persistence than GLP-1 receptor agonists in 14,998 matched patients, most clearly with cardiovascular disease.
Peer-reviewed -
Behavioural scienceSocial connection refines
Living alone and mortality in older Koreans: link lost after socioeconomic weighting
Among 3,771 older Koreans, living alone was linked to higher mortality, but not after weighting for income, education and area.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
Stimulant toxicity emergency visits followed by 2.1% one-year mortality, mostly overdose
Of 2,356 patients discharged after emergency visits for stimulant toxicity, 2.1% died within a year, two-thirds from overdose.
Peer-reviewed -
Behavioural scienceInfection and pandemics confirms
H5N1 avian influenza in US dairy herds clusters where non-waterfowl birds are abundant
Early US dairy H5N1 outbreaks sat in counties with more non-waterfowl birds than high-cattle-density counties without outbreaks.
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch use in US youth: flavours and convenience linked to more frequent use
US youth who tried nicotine pouches mostly cited experimentation, but flavours, convenience and feeling addicted were tied to frequent use.
Peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Semaglutide and tirzepatide prescriptions in adults with obesity often end within a year
Of 9,189 adults with obesity but no diabetes starting semaglutide or tirzepatide, 18.6% had coverage for 336 days or more.
Peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Accidental overdose admissions in New South Wales and later premature death by cause
Among 14,036 people hospitalised for accidental overdose in New South Wales, deaths ran at 3.5 times the expected rate.
Peer-reviewed -
Behavioural scienceDiet, exercise and sleep new
GLP-1/GIP use in US adults rose to 12% by 2025, a third via non-traditional access
GLP-1/GIP use rose from 8.2% to 12.0% of US adults in 18 months, led by weight-loss use.
Preprint · not peer-reviewed
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Data, models and systemsAI in medicine refines
NEWS early warning score and machine learning give similar net benefit for 24 h mortality
A gradient-boosting model flagged at most 1·9 more 24 h deaths per 10 000 patients than NEWS, in Danish hospitals.
Peer-reviewed -
Data, models and systemsHealth systems and access new
US health funding cuts in 2025 and HIV and TB service uptake in Kenya
After US health funding to Kenya stopped in early 2025, recorded HIV testing, prevention and treatment fell within two months.
Peer-reviewed -
Data, models and systemsValue in health new
Vitamin D for US adults with prediabetes saved costs in a lifetime microsimulation model
In a simulated US cohort with prediabetes, daily vitamin D3 lowered lifetime costs by $3208 per person and added 0.12 QALYs, assuming the 15% cut in diabetes risk seen in pooled trials.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Genome-wide study of 1,255 child and parental traits in 80,639 Japanese children
Genotyping of 80,639 Japanese children found 6,073 loci across 1,255 traits, 18-20% of them new associations.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine refines
Sybil deep learning model and biennial lung cancer screening in low-risk Lung-RADS scans
In 3,120 scans from one hospital, Sybil moved 33.8% of negative screens to biennial screening with no delayed cancers.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals new
Self-reported debt in UK survey data compared with credit reference agency records
Self-reported debt in a UK panel survey disagreed with credit reference records for some types, altering links with mental health.
Peer-reviewed -
Data, models and systemsForecasts and their record new
Women's health spending in poorer countries falls more steeply with debt service
In 71 poorer countries, each 1-point rise in debt service against GDP went with 4.2% lower women's health spending.
Peer-reviewed -
Data, models and systemsValue in health new
Prompt Mental Health Care in Norway likely cost-effective versus usual care over 3 years
Prompt Mental Health Care cost €23,809 per QALY over 1 year and €6,376 over 3 years in a 738-person trial.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Retinal deep learning biomarker estimates mortality risk and how it changes with age
RetiME, a deep learning model, maps retinal photographs to each person's mortality risk and how it changes with age.
Peer-reviewed -
Data, models and systemsValue in health new
Opioid use disorder medication in residential treatment modelled for Massachusetts
A model found offering opioid use disorder medication in Massachusetts residential centres, with outpatient linkage, cost $40,195 per QALY gained.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Care management algorithms trained on past utilisation under-select disadvantaged adults
Among 201,216 US adults, utilisation-trained algorithms under-selected disadvantaged groups, and a health status target nearly closed the Black-White gap.
Preprint · not peer-reviewed -
Data, models and systemsHealth systems and access new
Centenarians in France had fewer acute hospital stays per head in 2023 than in 2014
Acute hospital stays among French centenarians fell from 53.2 to 45.4 per 100 between 2014 and 2023.
Peer-reviewed -
Data, models and systemsForecasts and their record refines
Stroke mortality in Japan showed a modest excess in 2022, concentrated in older men
Japan recorded 3,434 excess stroke deaths in 2020-2022, almost all in 2022 and mostly among males aged 70 or over.
Peer-reviewed -
Data, models and systemsWhat linked data reveals confirms
Real spending on high-cost 'high-impact' medicines in Catalonia rose about 30%, 2019–2024
Nominal spending on high-impact medicines in Catalonia rose from €1.10 billion in 2019 to €1.69 billion in 2024.
Peer-reviewed -
Data, models and systemsValue in health refines
UK food tax designs modelled for effects on diet, health, NHS costs and inequality
Modelled UK food taxes cut 25 to 58 kcal a day; only the sugar and salt tax narrowed health inequalities.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Transcatheter aortic valve implantation in Japan: care needs, costs and mortality
After TAVI, Japanese patients in the most dependent care group had about five times the costs and higher mortality.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Multimorbidity after myocardial infarction clusters into three trajectories in UK Biobank
In 12 701 UK Biobank participants after myocardial infarction, three multimorbidity trajectories emerged; the SMART score predicted mortality better.
Peer-reviewed -
Data, models and systemsRevisions and new sources new
Electronic death certificates cut garbage codes in Norway's Cause of Death Registry
In Norwegian deaths, 2018-2023, electronic certificates were 21% less likely than paper ones to record a garbage code.
Peer-reviewed -
Data, models and systemsValue in health confirms
Lecanemab and donanemab for early Alzheimer's disease are not cost-effective in China
A lifetime Markov model found that neither lecanemab nor donanemab was cost-effective at current Chinese prices, from either perspective.
Peer-reviewed -
Data, models and systemsAI in medicine refines
AI-derived ECG features add little beyond automated ECG reports for 30-day mortality
Deep-learning ECG features beat simple morphology measurements for 30-day mortality, but added little over the ECG machine's own automated report.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Capivasertib with abiraterone: modelled $3,120,720 per QALY in PTEN-deficient mHSPC
In a US payer model, capivasertib plus abiraterone for PTEN-deficient mHSPC cost $3,120,720 per QALY gained.
Peer-reviewed -
Data, models and systemsValue in health refines
Hemgenix for haemophilia B costs more than factor IX prophylaxis over the first ten years
In a Swedish budget-impact model, Hemgenix cost more than factor IX prophylaxis over 10 years under every payment model.
Peer-reviewed -
Data, models and systemsAI in medicine new
SPARC transformer model uses routine measurements to predict cancer adverse events
A transformer model trained on 224,047 patients' routine measurements predicted cancer adverse events in prospective and external cohorts.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Influenza hospitalisation gaps by ethnic group in England partly run through deprivation
In England's 2023–24 vaccine-eligible cohort, deprivation mediated 26% of excess influenza hospitalisation odds in Pakistani and 41% in Bangladeshi groups.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Smoking-persistence polygenic score linked to an 8-year gap in median quitting age
Top-decile smokers on a smoking-persistence polygenic score quit at an adjusted median age 8 years older than bottom-decile smokers.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Dementia and emergency hospital use before and after diagnosis in North West London
Before dementia diagnosis, emergency admission rates were 5.35 times those of residents without dementia, rising to 6.67 times after diagnosis.
Preprint · not peer-reviewed -
Data, models and systemsValue in health confirms
Lecanemab for early Alzheimer's disease in China exceeds the cost-effectiveness threshold
Lecanemab added 1.24 QALYs in early Alzheimer's disease in China, but cost 372,609 yuan per QALY, above the threshold.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Respiratory infection hospitalisation risk in New Zealand predicted by gradient boosting
Gradient boosting models using demographics, morbidity indices and influenza vaccination status separated people with and without a respiratory infection hospitalisation, across about 5 million New Zealanders each year.
Preprint · not peer-reviewed -
Data, models and systemsForecasts and their record new
Alzheimer's disease model links slower cognitive decline to later institutionalisation
In a memory clinic microsimulation, 30% slower MMSE decline delayed institutional care by 1.1 years, with similar time spent there.
Peer-reviewed -
Data, models and systemsForecasts and their record refines
Ensemble models of expected US mortality were more accurate than single models
Using weekly US deaths for 2008–2024, ensemble models gave more accurate expected mortality, with better coverage, than single models.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Hepatitis C treatment in one US state's Medicaid rose as access restrictions ended
Hepatitis C treatment initiation in one US state's Medicaid rose as restrictions ended, but peaked at 23% for 2020 diagnoses.
Peer-reviewed -
Data, models and systemsHealth systems and access confirms
Neighbourhood deprivation and excess mortality after clinical risk adjustment in Medicare
Among 4,477,014 Medicare beneficiaries, excess mortality was 0.5 percentage points higher in the most deprived decile than the middle.
Peer-reviewed -
Data, models and systemsForecasts and their record new
People who inject drugs in the US: projected deaths, infections and costs, 2025-2034
A US microsimulation projects 487 249 deaths from injection drug use and $565 billion in healthcare costs over 2025–2034.
Peer-reviewed -
Data, models and systemsValue in health confirms
One-time CKD screening at age 55 in Finland: a lifetime cost-effectiveness model
Modelled one-time CKD screening of Finns aged 55, plus SGLT2i and RAASi treatment, cost €6,478 per quality-adjusted life year.
Peer-reviewed -
Data, models and systemsValue in health contradicts
Polygenic risk-guided prostate cancer screening was not cost-effective in a UK model
In a UK-calibrated microsimulation, prostate cancer screening guided by polygenic risk scores cost more and was less effective than alternatives.
Peer-reviewed
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Tomorrow's worldA changing climate new
Global heat-related mortality rose by 29% in very strong El Niño years
Estimated heat-related mortality rose 29% in very strong El Niño years, most in low- and medium-Human Development Index regions.
Peer-reviewed -
Tomorrow's worldA changing climate new
West Nile virus activity in Arizona linked to drought-monsoon cycles in modelling study
Models built on Arizona mosquito surveillance explained 65.3% of weekly variation in county-level human West Nile cases, one week ahead.
Preprint · not peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Digital interventions for low back pain compared across 84 randomised trials
Virtual reality cut pain intensity most against control at the end of treatment, rated with moderate confidence.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
ICU admissions in Germany and atmospheric factors across eleven bioclimatic regions
Air pressure and heat were the atmospheric factors most often linked to German intensive care admissions over 15 years.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate new
Temperature-attributable deaths in South Korea split by avoidable and non-avoidable cause
Nearly one-third of temperature-attributable deaths in South Korea in 1990-2023 fell in preventable or treatable causes.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
MIND diet adherence and later epigenetic ageing in the Health and Retirement Study
In 1,740 older US adults, higher 2013 MIND diet scores were associated with lower epigenetic ageing in 2016.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
Heatwave exposure of infants and older adults rose in Australia and New Zealand, 2016–2025
In 2021–2025, climate change accounted for 65% of heatwave days in Australia and 73% in New Zealand.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Indoor heat and mortality: a model mapping outdoor exposure-response curves indoors
Because indoor temperature rises less than outdoor temperature, a 1°C rise indoors may be linked to a larger mortality change than a 1°C rise outdoors.
Peer-reviewed -
Tomorrow's worldInnovation in treatment new
Individualised mRNA melanoma vaccine with pembrolizumab cuts recurrence or death by 42%
Adding intismeran autogene to pembrolizumab after melanoma was removed reduced recurrence or death risk by 42% in phase III INTerpath-0001.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Weather and child hospitalisation in Sweden: heat, intraday temperature swings and rain
Among 4,638,247 Swedish children, heat, very low or very high intraday temperature swings and more rain were linked to admissions.
Preprint · not peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
GrimAge epigenetic clock predicts survival in Dutch centenarians beyond cognition
Among 247 Dutch centenarians, higher GrimAge acceleration predicted higher mortality independently of cognition; adding MMSE improved survival stratification.
Preprint · not peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
Epigenetic clock changes correspond inconsistently to clinical changes in ageing studies
In human geroscience intervention studies, epigenetic-clock changes matched clinical-outcome changes inconsistently, and no study validated a clock as a surrogate.
Peer-reviewed -
Tomorrow's worldA changing climate new
Typhoon exposure and excess deaths in Japan, 2010–2019, by age and local vulnerability
Typhoon winds were linked to 2,426 excess deaths among Japanese adults aged 70 and over, against 301 recorded direct deaths.
Preprint · not peer-reviewed
