COIOS — COIOS - International risk research catalyst focused on health & longevity research
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Official figures
Where the evidence stands
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Forecasts and their record
How the forecasts are made, how well they explained the past, and how well mortality can be forecast — and by whom.
1 this week -
Innovation in treatment
Treatments that did not exist before — drugs, operations, devices — and whether they reach the people who would benefit.
2 this week -
Diet, exercise and sleep
What people eat and how much they move: what the measured evidence says each does to mortality, and what has been shown to change either.
2 this week -
Cancer
Where is cancer incidence rising and falling, what screening and new tests find earlier, and what treatment has done to survival.
6 this week -
What linked data reveals
What linked registries make it possible to know about whole populations
7 this week -
Obesity, diabetes and GLP-1
Are obesity and diabetes still rising, what behavioural change and public policy do, and what difference do GLP-1s and other similar drugs make.
6 this week -
Smoking and vaping
How far smoking has fallen and how many deaths it still causes, what vaping is doing to the people who take it up, and what generational bans will show.
3 this week -
Changing behaviour at scale
Whether new technology can change what people do at the scale of a population: apps, wearables, automated messages, digital programmes and platforms, and how far their effects last and reach.
5 this week -
AI in medicine
Whether machine learning predicts, detects and decides better than the tools we have, and whether that has yet changed an outcome for a population.
1 this week -
Heart and stroke
Whether deaths from heart disease and stroke have stopped falling, what is found earlier, what treatment and prevention do now, and what the deaths say.
3 this week -
Medicine at a distance
What wearables, remote monitoring and care at home add to how health is measured and delivered, and whether it shows in outcomes.
1 this week -
Alcohol and drug use
What is happening to deaths from alcohol, drugs and suicide, whether they move together, and how much of it is behaviour and how much circumstance.
1 this week -
Social connection
Isolation, loneliness and mortality: what the evidence shows, how far the relationship is causal, and what interventions have shown.
1 this week -
A changing climate
How air pollution, heat and cold affect deaths and survival, how the attribution is made, and how the balance is changing.
1 this week -
Mental health
Deaths by suicide, the life expectancy gap in severe mental illness, and the physical disease that follows it: what mental illness costs in lives.
5 this week -
Health systems and access
What the health system can provide, who gets it, and whether the gaps in health between groups are widening.
5 this week -
Infection and pandemics
Infection and pandemics: the risks, and how well prepared we are
9 this week -
Value in health
What a treatment, health programme or policy is worth against what it costs, and how far the models that decide it can be trusted.
4 this week -
Slowing ageing itself
Whether anything yet slows ageing itself, rather than treating one disease at a time, and how we would know if it did.
1 this week -
Dementia
Whether dementia is becoming more or less common, what is now found, what treatment and prevention do, and what the deaths say.
1 this week -
Revisions and new sources
What the figures are built from, what is newly available, and how much the numbers move when they are revised.
20 this week -
Adherence and persistence
Whether a treatment is actually taken, for how long, and what changes either.
3 this week -
Frailty and multimorbidity
Whether the years added after 85 are healthy ones, how frailty and multiple conditions are measured, and where the data run out.
1 this week
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Health todayMental health refines
Severe mental illness costs Norwegian men 1.5 to 19.9 life-years depending on subgroup
In a Norwegian registry cohort of 2,486,836 adults followed from 2008 to 2023, excess life-years lost from age 30 in men ranged from 1.50 for depression with non-inpatient care and university education to 19.86 for schizophrenia with inpatient care and less than high school education.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence new
Most adults starting semaglutide or tirzepatide did not continue for a year
Among 743,153 US adults starting semaglutide or tirzepatide for obesity in 2024, 29.9% and 35.9% respectively were still being prescribed the drug at 12 months.
Preprint · not peer-reviewed -
Data, models and systemsHealth systems and access new
Twelve-hour emergency stays carry 1.95 times the hospitalisation risk over two years
Among 3,347,008 working-age adults attending emergency departments in England, stays of 12 hours or more carried 1.95 times the hospitalisation risk over two years, compared with stays under two hours.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
Summer heat in Italy raises deaths from nervous system and mental illness
Across 7,864 Italian municipalities over 20 summers, heat-attributable fractions were highest for nervous system diseases at 14.93% and mental and behavioural disorders at 14.47%.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep new
Weight-management texts did not reduce weight in postpartum women over 12 months
Among 892 postpartum women with a BMI of 25 or more, 12 months of automated weight-management texts made no difference to weight against texts on child health (-0.1 kg).
Preprint · not peer-reviewed -
Health todayCancer new
Menopausal hormone therapy users had higher breast cancer incidence but lower mortality
In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch take-up is higher among US adults using other tobacco products
In the PATH study of 24,640 US adults, those using smokeless tobacco only took up oral nicotine pouches at 42.4 times the rate of adults using no other tobacco product.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep refines
Moving 30 minutes from sleep to activity linked to lower mortality in adequate sleepers
In 68,995 UK Biobank adults with accelerometer-measured behaviour, moving 30 minutes from sleep to moderate-to-vigorous activity carried an all-cause mortality hazard ratio of 0.80 among those meeting sleep guidelines, but among short sleepers such shifts were linked to higher CVD mortality.
Peer-reviewed -
Tomorrow's worldChanging behaviour at scale refines
Dutch infant vaccination uptake fell during the pandemic and again after it
Children in the Netherlands due their first diphtheria-tetanus-pertussis-polio dose after the pandemic had a fifth the odds of vaccination by six months of their pre-pandemic siblings.
Peer-reviewed -
Data, models and systemsValue in health new
Modelled extra HPV doses for women with HIV averted cervical cancer
A Markov model of 13 African countries found that extra HPV doses for women living with HIV averted cervical cancer beyond routine vaccination at 14, at added programme cost.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
Modelled early pandemic costs rise more from too little control than from too much
In models fitted to first-year COVID-19 cases in 110 countries, controlling transmission five points below the cost-optimal level carried excess costs above 400%, against 10-80% five points above.
Preprint · not peer-reviewed -
Health todayDementia new
Dementia mortality is higher where outdoor ultrafine particle levels are higher
In 2.1 million adults in Montreal and Toronto, each 10,000 particle/cm3 increase in outdoor ultrafine particle concentration was associated with a 22% higher rate of dementia mortality.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Oral safiglipron lowered HbA1c as much as dapagliflozin, and more at 90 mg
In adults with type 2 diabetes, once-daily oral safiglipron lowered HbA1c at least as much as dapagliflozin, and by more at the 90 mg dose.
Peer-reviewed -
Data, models and systemsRevisions and new sources new
Real cigarette prices rose 2.9% a year worldwide between 2008 and 2024
A panel analysis of most-sold-brand cigarette prices across 195 countries found inflation-adjusted international dollar prices rising 2.9% a year from 2008 to 2024, with over a fifth of nominal prices unchanged between successive periods and up to 40% in the African region.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Older adults starting GLP-1 drugs were younger and heavier than other initiators
Among 58,754 adults aged 65 and over with type 2 diabetes, mean BMI at initiation was 33.8 for GLP-1 drugs as compared to 29.7 for SGLT2 inhibitors.
Preprint · not peer-reviewed -
Health todayCancer refines
Under 2 mm of Gleason pattern 4 matches favourable intermediate-risk prostate cancer
Among 2499 men with Grade Group 2-4 prostate cancer, those with under 2 mm of Gleason pattern 4 had 5-year biochemical recurrence of 20%, matching favourable intermediate-risk disease.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
RSV and rhinovirus caused more Brazilian respiratory deaths in 2026 than influenza
Brazilian surveillance over 35 weeks of 2026 recorded more severe respiratory deaths from RSV and rhinovirus than from influenza, concentrated in children under 2 and those aged 65 and over.
Preprint · not peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
One in seven Danish anorexia patients became steadily more ill after diagnosis
Among 9,534 Danish patients with anorexia nervosa, one in seven became steadily more ill, with more psychiatric and physical illness in the five years after diagnosis.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
An estimated 1.32% of US adults had hepatitis C in 2017-2020
An estimated 1.32% of US adults, or 3.33 million people, had hepatitis C over 2017-2020, on a model combining six surveillance, claims and Medicaid sources.
Preprint · not peer-reviewed -
Tomorrow's worldMedicine at a distance new
Virtual ward patients aged 70+ reported fewer depressive symptoms than inpatients
In a single-trust audit of 100 patients aged 70 and over, 72% of hospital inpatients scored 5 or more on the GDS-15 compared with 30% of those managed on a virtual ward, an unadjusted odds ratio of 6.00 (95% CI 2.53-14.24).
Peer-reviewed
-
Health todayMental health refines
Severe mental illness costs Norwegian men 1.5 to 19.9 life-years depending on subgroup
In a Norwegian registry cohort of 2,486,836 adults followed from 2008 to 2023, excess life-years lost from age 30 in men ranged from 1.50 for depression with non-inpatient care and university education to 19.86 for schizophrenia with inpatient care and less than high school education.
Preprint · not peer-reviewed -
Health todayCancer new
Menopausal hormone therapy users had higher breast cancer incidence but lower mortality
In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
Preprint · not peer-reviewed -
Health todayDementia new
Dementia mortality is higher where outdoor ultrafine particle levels are higher
In 2.1 million adults in Montreal and Toronto, each 10,000 particle/cm3 increase in outdoor ultrafine particle concentration was associated with a 22% higher rate of dementia mortality.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Oral safiglipron lowered HbA1c as much as dapagliflozin, and more at 90 mg
In adults with type 2 diabetes, once-daily oral safiglipron lowered HbA1c at least as much as dapagliflozin, and by more at the 90 mg dose.
Peer-reviewed -
Health todayCancer refines
Under 2 mm of Gleason pattern 4 matches favourable intermediate-risk prostate cancer
Among 2499 men with Grade Group 2-4 prostate cancer, those with under 2 mm of Gleason pattern 4 had 5-year biochemical recurrence of 20%, matching favourable intermediate-risk disease.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
One in seven Danish anorexia patients became steadily more ill after diagnosis
Among 9,534 Danish patients with anorexia nervosa, one in seven became steadily more ill, with more psychiatric and physical illness in the five years after diagnosis.
Preprint · not peer-reviewed -
Health todayMental health new
Infection followed hip fracture in 43% of older Danish patients with dementia
Among 100,335 Danish hip fracture patients aged 65 and over, infection within 30 days reached 43.0% in those with dementia, as compared to 18.4% in matched comparators with dementia.
Peer-reviewed -
Health todayCancer new
PSMA-guided radiotherapy did not improve failure-free survival in prostate cancer
In a phase 2 trial of 253 men, radiotherapy targeted to every lesion seen on PSMA-PET gave five-year failure-free survival of 66% against 62% for standard care.
Peer-reviewed -
Health todayHeart and stroke refines
STEMI patients judged at high risk of shock had double the ten-year mortality
Among 1,574 Danish STEMI patients treated by primary angioplasty, those a score marked as at high risk of shock in hospital had ten-year mortality of 41% against 20%.
Peer-reviewed -
Health todayHeart and stroke confirms
US deaths recording both type 2 diabetes and cardiac arrest rose faster after 2014
Deaths of US adults recording both type 2 diabetes and cardiac arrest rose by 2.72% a year to 2014, then by 9.55% a year to 2020.
Peer-reviewed -
Health todayHeart and stroke new
Japanese romosozumab starters had less recent heart attack or stroke than other users
Among 311,585 Japanese patients starting romosozumab between 2019 and 2023, 11.7% of men and 7.9% of women had a myocardial infarction or stroke in the prior 360 days, below the 8.9-17.6% among users of other osteoporosis drugs, and those with such a history discontinued more often.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 confirms
German child overweight and obesity prevalence is 16.1% and stable over two decades
Measured height and weight in 3,978 representative German children aged 4 to 17 in 2023 to 2025 gave an overweight and obesity prevalence of 16.1% and an obesity prevalence of 6.7%, which the authors report as stable against waves dating back to 2005.
Preprint · not peer-reviewed -
Health todayCancer confirms
Multi-cancer blood test detected 15.4% of stage I cancers at 98.5% specificity
A methylation and protein multi-cancer early detection blood test, assessed in a prospectively collected case-control study of 6,352 samples across 21 tumour types, had overall sensitivity of 50.9% at 98.5% specificity, rising from 15.4% at stage I to 85.5% at stage IV.
Peer-reviewed -
Health todayMental health refines
Depression carried a 65% higher rate of new cardiometabolic disease over 15 years
Among 1858 Dutch adults followed for 15 years, lifetime major depression was associated with higher cardiometabolic disease incidence (HR 1.65), with no one symptom pattern carrying more risk than another.
Peer-reviewed -
Health todayCancer refines
England's cervical screening coverage gap by deprivation has widened to 7.4 points
Cervical screening coverage in England in 2024 ranged from 73.5% in the least deprived areas to 66.1% in the most deprived, a wider gap than that recorded twelve years earlier.
Peer-reviewed
-
Behavioural scienceAdherence and persistence new
Most adults starting semaglutide or tirzepatide did not continue for a year
Among 743,153 US adults starting semaglutide or tirzepatide for obesity in 2024, 29.9% and 35.9% respectively were still being prescribed the drug at 12 months.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep new
Weight-management texts did not reduce weight in postpartum women over 12 months
Among 892 postpartum women with a BMI of 25 or more, 12 months of automated weight-management texts made no difference to weight against texts on child health (-0.1 kg).
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch take-up is higher among US adults using other tobacco products
In the PATH study of 24,640 US adults, those using smokeless tobacco only took up oral nicotine pouches at 42.4 times the rate of adults using no other tobacco product.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep refines
Moving 30 minutes from sleep to activity linked to lower mortality in adequate sleepers
In 68,995 UK Biobank adults with accelerometer-measured behaviour, moving 30 minutes from sleep to moderate-to-vigorous activity carried an all-cause mortality hazard ratio of 0.80 among those meeting sleep guidelines, but among short sleepers such shifts were linked to higher CVD mortality.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Modelled early pandemic costs rise more from too little control than from too much
In models fitted to first-year COVID-19 cases in 110 countries, controlling transmission five points below the cost-optimal level carried excess costs above 400%, against 10-80% five points above.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Older adults starting GLP-1 drugs were younger and heavier than other initiators
Among 58,754 adults aged 65 and over with type 2 diabetes, mean BMI at initiation was 33.8 for GLP-1 drugs as compared to 29.7 for SGLT2 inhibitors.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
RSV and rhinovirus caused more Brazilian respiratory deaths in 2026 than influenza
Brazilian surveillance over 35 weeks of 2026 recorded more severe respiratory deaths from RSV and rhinovirus than from influenza, concentrated in children under 2 and those aged 65 and over.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
An estimated 1.32% of US adults had hepatitis C in 2017-2020
An estimated 1.32% of US adults, or 3.33 million people, had hepatitis C over 2017-2020, on a model combining six surveillance, claims and Medicaid sources.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics confirms
VAERS reports after the 2024-25 COVID-19 vaccine were consistent with earlier seasons
A CDC review of 9856 US VAERS reports following the 2024-2025 JN.1-based COVID-19 vaccine found 8.9% serious, eight Guillain-Barre and six myocarditis or myopericarditis cases meeting case definitions, with reporting rates below background rates for both.
Peer-reviewed -
Behavioural scienceSmoking and vaping new
One in five Australian paediatricians surveyed provides vaping cessation support
Of 90 paediatricians and registrars surveyed across Australia in 2023, over two-thirds routinely advised adolescents against vaping, but only one in five provided cessation support.
Peer-reviewed -
Behavioural scienceInfection and pandemics confirms
Digital reminders raised child vaccination coverage in low- and middle-income countries
A meta-analysis of 22 randomised trials covering 68,664 participants found digital reminders raised childhood immunisation coverage in low- and middle-income countries (RR 1.27, 95% CI 1.09 to 1.49), and more so with education (RR 1.72), with substantial heterogeneity.
Peer-reviewed -
Behavioural scienceSocial connection confirms
Two loneliness scales agree on most correlates in 135,725 volunteers, not on education
A cross-sectional analysis of 135,725 adult volunteers in England found younger age, being single, unemployed or disabled associated with higher loneliness on both scales, while university education was associated with higher loneliness on UCLA but lower on the ONS direct measure.
Peer-reviewed -
Behavioural scienceAlcohol and drug use confirms
Norway's total alcohol advertising ban has held for 50 years through legal challenges
A review of Norwegian government documents, parliamentary debate and court rulings traces the comprehensive alcohol marketing ban in force since July 1975, finding it has withstood repeated legal challenge and been extended to alcohol-free beers and social media.
Peer-reviewed -
Behavioural scienceSmoking and vaping refines
Seven in ten Korean heated tobacco and cigarette users moved to cigarettes
Among 7.26 million Korean adults screened between 2019 and 2023, users of heated tobacco or e-cigarettes were more likely to quit cigarettes, but also more likely to start smoking again.
Peer-reviewed -
Behavioural scienceAdherence and persistence new
Fewer than one in five US stroke and TIA patients filled a P2Y12 inhibitor
Among 45,763 US adults with a first ischaemic stroke or TIA, 18.9% filled a P2Y12 inhibitor within 30 days, and half of clopidogrel initiators had stopped filling by 180 days.
Peer-reviewed
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Data, models and systemsHealth systems and access new
Twelve-hour emergency stays carry 1.95 times the hospitalisation risk over two years
Among 3,347,008 working-age adults attending emergency departments in England, stays of 12 hours or more carried 1.95 times the hospitalisation risk over two years, compared with stays under two hours.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Modelled extra HPV doses for women with HIV averted cervical cancer
A Markov model of 13 African countries found that extra HPV doses for women living with HIV averted cervical cancer beyond routine vaccination at 14, at added programme cost.
Preprint · not peer-reviewed -
Data, models and systemsRevisions and new sources new
Real cigarette prices rose 2.9% a year worldwide between 2008 and 2024
A panel analysis of most-sold-brand cigarette prices across 195 countries found inflation-adjusted international dollar prices rising 2.9% a year from 2008 to 2024, with over a fifth of nominal prices unchanged between successive periods and up to 40% in the African region.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine new
Machine learning screen finds 17 dietary polyphenols that bind Salmonella proteins
A graph neural network screened over 7,000 plant compounds, and laboratory binding assays confirmed that 17 dietary polyphenols attach to two proteins Salmonella uses to coordinate its virulence.
Peer-reviewed -
Data, models and systemsValue in health new
Treating drug-resistant TB contacts up to age 45 was modelled as cost-effective
A model of 189 countries found that offering preventive treatment to household contacts of drug-resistant tuberculosis up to age 45, rather than only under-15s, was cost-effective in 160 countries.
Preprint · not peer-reviewed -
Data, models and systemsForecasts and their record new
Nigeria's adolescent HPV programme is modelled to avert 1.82m cervical cancers by 2100
An agent-based microsimulation calibrated to Nigeria projects that continuing single-dose adolescent HPV vaccination averts 1.82 million cervical cancer cases over 2025 to 2100, a 53% reduction, while 945,000 residual cases fall in women already beyond target age.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Tuberculosis vaccine VPM1002 is modelled as stronger against disease outside the lungs
A dynamic model of tuberculosis in India estimated the VPM1002 vaccine to be 42.9% effective against disease outside the lungs and 14.0% against lung disease, both intervals including no effect.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Sotagliflozin after worsening heart failure is modelled at $75,510 per QALY gained
A lifetime microsimulation of patients with type 2 diabetes after worsening heart failure put sotagliflozin at $75,510 per quality-adjusted life-year gained, at an assumed net cost of $434 a month.
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Never starting anticoagulants in atrial fibrillation carried the highest annual costs
Among 47,427 Scots with incident atrial fibrillation, annual healthcare costs were GBP 7,288 per patient on continuous oral anticoagulation and GBP 22,751 for those never started on it.
Peer-reviewed -
Data, models and systemsAI in medicine new
A blood protein score of cellular ageing predicted death in UK Biobank
A blood protein score of cellular ageing, built in UK Biobank, predicted death and later dementia, COPD, heart attack and stroke, and changed over 18 months with exercise.
Peer-reviewed -
Data, models and systemsHealth systems and access confirms
Childhood disadvantage carried a 26% higher rate of adult all-cause mortality
A meta-analysis of 102 cohort studies covering about 8.5 million people in 24 countries found adult all-cause mortality 26% higher for those whose fathers held the lowest-ranked occupations, with a relative index of inequality of 2.33 for childhood economic circumstances.
Peer-reviewed -
Data, models and systemsAI in medicine new
Language models identified overdose deaths from New York investigators' written reports
Reading the reports New York City death investigators write on each case, the better of two language models identified suspected overdose deaths with 92% sensitivity and 88% positive predictive value.
Peer-reviewed -
Data, models and systemsValue in health new
Modelled depression screening of KwaZulu-Natal sex workers averts HIV at $490 per QALY
A transmission model for KwaZulu-Natal found depression screening with behavioural treatment most cost-effective among female sex workers, at $350 per HIV infection averted and $490 per QALY gained.
Peer-reviewed -
Data, models and systemsValue in health new
Modelled hepatitis B cure is cost-effective under USD46,642 a course in the US
A Markov model estimated that a hepatitis B cure regimen working in 30% of patients would be cost-effective at a one-off price below USD46,642 in the US.
Peer-reviewed -
Data, models and systemsRevisions and new sources new
Electronic death notification in Zambia lifted completeness from 11.9% to 17.4%
An electronic version of Zambia's death notification form, used in burial offices across four provinces, cut the mean reporting delay from six days to three.
Peer-reviewed
-
Tomorrow's worldA changing climate refines
Summer heat in Italy raises deaths from nervous system and mental illness
Across 7,864 Italian municipalities over 20 summers, heat-attributable fractions were highest for nervous system diseases at 14.93% and mental and behavioural disorders at 14.47%.
Preprint · not peer-reviewed -
Tomorrow's worldChanging behaviour at scale refines
Dutch infant vaccination uptake fell during the pandemic and again after it
Children in the Netherlands due their first diphtheria-tetanus-pertussis-polio dose after the pandemic had a fifth the odds of vaccination by six months of their pre-pandemic siblings.
Peer-reviewed -
Tomorrow's worldMedicine at a distance new
Virtual ward patients aged 70+ reported fewer depressive symptoms than inpatients
In a single-trust audit of 100 patients aged 70 and over, 72% of hospital inpatients scored 5 or more on the GDS-15 compared with 30% of those managed on a virtual ward, an unadjusted odds ratio of 6.00 (95% CI 2.53-14.24).
Peer-reviewed -
Tomorrow's worldInnovation in treatment new
Oral orforglipron is tested for cardiovascular safety against insulin in type 2 diabetes
A phase 3 trial randomised 2749 adults with type 2 diabetes and heart or kidney disease to oral orforglipron or insulin glargine, and followed them for a median two years.
Peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Digital interventions after stroke were linked to 5.8 mmHg lower systolic pressure
A meta-analysis of 29 studies and 8,389 stroke or TIA survivors found digital health interventions associated with a pooled 5.8 mmHg lower systolic blood pressure (95% CI -9.9 to -1.6), with prediction intervals crossing the null and no consistent effect on lipids or weight.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
Proteomic organ clocks tracked 16-year mortality less closely than epigenetic age
Accelerated liver, immune and heart proteomic ageing carried hazard ratios of 1.38 to 1.43 per standard deviation for 16-year mortality, below those for epigenetic age and cognition.
Peer-reviewed -
Tomorrow's worldA changing climate new
Daily cancer deaths in Japan were 0.88% higher per 10 micrograms/m3 of PM2.5
A 10 microgram per cubic metre rise in PM2.5 was associated with 0.88% more cancer deaths in Japan, though the association did not survive adjustment for NO2 or SO2.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself new
Uncertainty in a biological age estimate is itself associated with mortality
In over 450,000 UK Biobank participants, the uncertainty of a biological age estimate was associated with mortality, multimorbidity and loss of healthspan independently of the age gap itself.
Preprint · not peer-reviewed -
Tomorrow's worldChanging behaviour at scale new
Offering HPV vaccine at 9-10 raised series completion by age 13 from 45% to 62%
In a cluster-randomised trial across 31 US paediatric practices, introducing HPV vaccination at ages 9-10 rather than 11-12 brought median series completion forward from 13.3 to 12.2 years and raised completion by age 13 from 45.1% to 61.6%.
Preprint · not peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Pacemakers after cardiac surgery carry higher later death and heart failure risk
Among 76 223 Swedish adults having cardiac surgery, the 2.8% given a pacemaker within 30 days had a higher adjusted risk of death and of heart failure admission over 6.8 years.
Peer-reviewed -
Tomorrow's worldChanging behaviour at scale refines
Stroke prevention texts raised cardiovascular check-ups, an online course did not
In an Australian trial of 941 adults aged 45 and over, self-reported visits for cardiovascular risk assessment were 41.3% in the text message arm as compared to 29.0% in control.
Peer-reviewed -
Tomorrow's worldChanging behaviour at scale new
Social media alerts driven by wastewater data did not raise seasonal vaccination
A county-randomised trial across 40 New York State counties found that an 11-week campaign of wastewater-triggered social media alerts made no difference to COVID-19 or influenza vaccination over the season.
Preprint · not peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Exercise-based telerehabilitation raised peak oxygen uptake in cardiac patients
Telerehabilitation with exercise at its core raised peak oxygen uptake by 2.58 mL/kg/min in 13 randomised trials of 958 adults with cardiovascular disease, although the prediction interval crossed zero.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Particulate matter shows no overall association with venous thromboembolism
An updated meta-analysis of 19 observational studies covering more than 4.5 million people found no significant overall association between long-term particulate exposure and venous thromboembolism, with a modest one appearing only among studies reporting in the same units.
Peer-reviewed -
Tomorrow's worldChanging behaviour at scale refines
RSV awareness tracked with vaccination in White and Black women, not Hispanic women
Among 650 pregnant and postpartum US women, RSV awareness was associated with a 26.4 point higher vaccination probability for White women but a non-significant 6.9 points for Hispanic women.
Peer-reviewed
