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Health todayMental health refines
Severe mental illness costs Norwegian men 1.5 to 19.9 life-years depending on subgroup
In a Norwegian registry cohort of 2,486,836 adults followed from 2008 to 2023, excess life-years lost from age 30 in men ranged from 1.50 for depression with non-inpatient care and university education to 19.86 for schizophrenia with inpatient care and less than high school education.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence new
Most adults starting semaglutide or tirzepatide did not continue for a year
Among 743,153 US adults starting semaglutide or tirzepatide for obesity in 2024, 29.9% and 35.9% respectively were still being prescribed the drug at 12 months.
Preprint · not peer-reviewed -
Health todayCancer new
Menopausal hormone therapy users had higher breast cancer incidence but lower mortality
In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Modelled extra HPV doses for women with HIV averted cervical cancer
A Markov model of 13 African countries found that extra HPV doses for women living with HIV averted cervical cancer beyond routine vaccination at 14, at added programme cost.
Preprint · not peer-reviewed -
Health todayDementia new
Dementia mortality is higher where outdoor ultrafine particle levels are higher
In 2.1 million adults in Montreal and Toronto, each 10,000 particle/cm3 increase in outdoor ultrafine particle concentration was associated with a 22% higher rate of dementia mortality.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Oral safiglipron lowered HbA1c as much as dapagliflozin, and more at 90 mg
In adults with type 2 diabetes, once-daily oral safiglipron lowered HbA1c at least as much as dapagliflozin, and by more at the 90 mg dose.
Peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Older adults starting GLP-1 drugs were younger and heavier than other initiators
Among 58,754 adults aged 65 and over with type 2 diabetes, mean BMI at initiation was 33.8 for GLP-1 drugs as compared to 29.7 for SGLT2 inhibitors.
Preprint · not peer-reviewed -
Health todayCancer refines
Under 2 mm of Gleason pattern 4 matches favourable intermediate-risk prostate cancer
Among 2499 men with Grade Group 2-4 prostate cancer, those with under 2 mm of Gleason pattern 4 had 5-year biochemical recurrence of 20%, matching favourable intermediate-risk disease.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
One in seven Danish anorexia patients became steadily more ill after diagnosis
Among 9,534 Danish patients with anorexia nervosa, one in seven became steadily more ill, with more psychiatric and physical illness in the five years after diagnosis.
Preprint · not peer-reviewed -
Tomorrow's worldMedicine at a distance new
Older patients on a virtual ward reported fewer depressive symptoms than inpatients
Among 100 patients aged 70 and over, 72% of hospital inpatients screened positive for depressive symptoms as compared to 30% of those cared for on a virtual ward.
Peer-reviewed -
Health todayMental health new
Infection followed hip fracture in 43% of older Danish patients with dementia
Among 100,335 Danish hip fracture patients aged 65 and over, infection within 30 days reached 43.0% in those with dementia, as compared to 18.4% in matched comparators with dementia.
Peer-reviewed -
Health todayCancer new
PSMA-guided radiotherapy did not improve failure-free survival in prostate cancer
In a phase 2 trial of 253 men, radiotherapy targeted to every lesion seen on PSMA-PET gave five-year failure-free survival of 66% against 62% for standard care.
Peer-reviewed
