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Health todayHeart and stroke refines
STEMI patients judged at high risk of shock had double the ten-year mortality
Among 1,574 Danish STEMI patients treated by primary angioplasty, those a score marked as at high risk of shock in hospital had ten-year mortality of 41% against 20%.
Peer-reviewed -
Health todayHeart and stroke confirms
US deaths recording both type 2 diabetes and cardiac arrest rose faster after 2014
Deaths of US adults recording both type 2 diabetes and cardiac arrest rose by 2.72% a year to 2014, then by 9.55% a year to 2020.
Peer-reviewed -
Health todayHeart and stroke new
Japanese romosozumab starters had less recent heart attack or stroke than other users
Among 311,585 Japanese patients starting romosozumab between 2019 and 2023, 11.7% of men and 7.9% of women had a myocardial infarction or stroke in the prior 360 days, below the 8.9-17.6% among users of other osteoporosis drugs, and those with such a history discontinued more often.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 confirms
Overweight/obesity in German children stands at 16.1%, unchanged over two decades
Measured height and weight in a representative sample of 3,978 German children aged 4 to 17 gave an overweight and obesity prevalence of 16.1%, with obesity alone at 6.7%.
Preprint · not peer-reviewed -
Health todayCancer confirms
Multi-cancer early detection blood test detected 15.4% of stage I cancers
A methylation and protein blood test identified 50.9% of cancers across 21 tumour organ types at a specificity of 98.5%, in a multi-centre case-control study of 6,352 samples.
Peer-reviewed -
Data, models and systemsForecasts and their record new
Nigeria's HPV programme is modelled to avert 1.82 million cervical cancers
Continuing to vaccinate Nigerian girls aged 9 to 14 is projected to avert 1.82 million cervical cancer cases to 2100, with 945,000 remaining in women already too old.
Preprint · not peer-reviewed -
Health todayMental health refines
Depression carried a 65% higher rate of new cardiometabolic disease over 15 years
Among 1858 Dutch adults followed for 15 years, lifetime major depression was associated with higher cardiometabolic disease incidence (HR 1.65), with no one symptom pattern carrying more risk than another.
Peer-reviewed -
Tomorrow's worldInnovation in treatment new
Oral orforglipron is tested for cardiovascular safety against insulin in type 2 diabetes
A phase 3 trial randomised 2749 adults with type 2 diabetes and heart or kidney disease to oral orforglipron or insulin glargine, and followed them for a median two years.
Peer-reviewed -
Data, models and systemsValue in health new
Sotagliflozin after worsening heart failure is modelled at $75,510 per QALY gained
A lifetime microsimulation of patients with type 2 diabetes after worsening heart failure put sotagliflozin at $75,510 per quality-adjusted life-year gained, at an assumed net cost of $434 a month.
Peer-reviewed -
Health todayCancer refines
England's cervical screening coverage gap by deprivation has widened to 7.4 points
Cervical screening coverage in England in 2024 ranged from 73.5% in the least deprived areas to 66.1% in the most deprived, a wider gap than that recorded twelve years earlier.
Peer-reviewed -
Health todayHeart and stroke refines
Never starting anticoagulants in atrial fibrillation carried the highest annual costs
Among 47,427 Scots with incident atrial fibrillation, annual healthcare costs were GBP 7,288 per patient on continuous oral anticoagulation and GBP 22,751 for those never started on it.
Peer-reviewed -
Health todayHeart and stroke refines
Weight loss in impaired glucose tolerance went with fewer deaths over 34 years
In 540 Chinese adults with impaired glucose tolerance, a weight loss of 5% or more over six years carried a hazard ratio for death of 0.67 against no weight loss.
Peer-reviewed
