-
Data, models and systemsValue in health contradicts
Polygenic risk-guided prostate cancer screening was not cost-effective in a UK model
In a UK-calibrated microsimulation, prostate cancer screening guided by polygenic risk scores cost more and was less effective than alternatives.
Peer-reviewed -
Health todayDementia refines
Education and dementia: a schooling reform cut incidence and weakened genetic risk
A compulsory schooling reform showed that extra education lowered dementia incidence and weakened the link between genetic risk and dementia.
Peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch use in British quit attempts rose 2021-2026, notably among 18-24s and men
Among British adults trying to stop smoking, pouch use nearly tripled to 6.7%, with an uncertain adjusted link to quitting.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals new
Scottish cohort of 3.7 million adults links disability and household setting to COVID-19
A linked cohort of 3,719,651 Scottish adults describes COVID-19 outcomes by disability group and household living arrangements.
Peer-reviewed -
Data, models and systemsWhat linked data reveals contradicts
Polygenic modification of statin benefit may arise from trial eligibility criteria
Simulations with no true interaction reproduced the reported pattern of greater lipid-lowering benefit at higher coronary artery disease polygenic risk.
Preprint · not peer-reviewed -
Health todayFrailty and multimorbidity refines
Plant-based diet indices and frailty in 8,628 older adults across three ageing cohorts
Higher overall plant-based scores were associated with lower frailty risk (ORs 0.71-0.80), unhealthful scores with higher risk (1.24-1.41).
Peer-reviewed -
Data, models and systemsWhat linked data reveals refines
Primary care death records match ONS registrations for 88% of deaths in OpenSAFELY-TPP
Of 1,409,275 ONS-registered deaths from 2020 to 2025, 88% had the same date of death in primary care and 8% had none.
Preprint · not peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Tirzepatide price rise shifted UK self-paying patients to semaglutide
Among 1,033,522 UK adults self-funding GLP-1 treatment, semaglutide initiation rose 31 percentage points in the month tirzepatide's list price rose.
Peer-reviewed -
Data, models and systemsValue in health new
NHS online diabetes self-management service modelled at £13,192 per QALY
A patient-level simulation of an NHS online service for type 2 diabetes estimated a gain of 0.016 QALYs and a net cost of £216 per user.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
Worklessness through ill health in England rose fastest among non-drinkers, 2014 to 2025
Health-related economic inactivity doubled among non-drinkers and low-risk drinkers, while falling among those drinking at levels indicating possible dependence.
Peer-reviewed -
Tomorrow's worldA changing climate new
More days above the WHO daily NO2 guideline are followed by faster cognitive decline
Among 12,235 English adults aged 50 and over, more days above the WHO daily NO2 guideline were followed by faster decline in memory and fluency, independent of annual mean exposure.
Preprint · not peer-reviewed -
Health todayFrailty and multimorbidity new
Sixty of 99 dietary factors are associated with hip fracture in UK women
Among 541,887 UK postmenopausal women followed for about 20 years, 60 of 99 dietary factors were associated with hip fracture risk after correction for multiple testing.
Peer-reviewed
