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Behavioural scienceDiet, exercise and sleep refines
Mid-life exercise of about an hour a day reduces hip fracture risk
In 324,284 UK Biobank adults followed for 16 years, hip fracture risk was lowest at about one hour a day of leisure-time activity, with no further reduction at higher volumes.
Preprint · not peer-reviewed -
Data, models and systemsHealth systems and access new
GP requests for specialist advice led to later diagnoses than referral alone
Among 71,145 patients in English primary care records, those whose GP sought specialist advice before referring were diagnosed later than those referred electively, by 15.9 weeks for inflammatory bowel disease.
Preprint · not peer-reviewed -
Data, models and systemsHealth systems and access new
Twelve-hour emergency stays carry 1.95 times the hospitalisation risk over two years
Among 3,347,008 working-age adults attending emergency departments in England, stays of 12 hours or more carried 1.95 times the hospitalisation risk over two years, compared with stays under two hours.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep new
Weight-management texts did not reduce weight in postpartum women over 12 months
Among 892 postpartum women with a BMI of 25 or more, 12 months of automated weight-management texts made no difference to weight against texts on child health (-0.1 kg).
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep refines
Swapping sleep for activity relates to mortality differently in short sleepers
Among UK Biobank adults meeting sleep duration guidelines, moving 30 minutes from sleep to moderate or vigorous activity carried an all-cause mortality hazard ratio of 0.80.
Peer-reviewed -
Tomorrow's worldMedicine at a distance new
Older patients on a virtual ward reported fewer depressive symptoms than inpatients
Among 100 patients aged 70 and over, 72% of hospital inpatients screened positive for depressive symptoms as compared to 30% of those cared for on a virtual ward.
Peer-reviewed -
Behavioural scienceSocial connection confirms
Two ways of asking about loneliness disagree over graduates in England
Among 135,725 adult volunteers in England, university education was associated with higher loneliness on a three-question scale but with lower loneliness when people were asked directly.
Peer-reviewed -
Health todayCancer refines
England's cervical screening coverage gap by deprivation has widened to 7.4 points
Cervical screening coverage in England in 2024 ranged from 73.5% in the least deprived areas to 66.1% in the most deprived, a wider gap than that recorded twelve years earlier.
Peer-reviewed -
Health todayHeart and stroke refines
Never starting anticoagulants in atrial fibrillation carried the highest annual costs
Among 47,427 Scots with incident atrial fibrillation, annual healthcare costs were GBP 7,288 per patient on continuous oral anticoagulation and GBP 22,751 for those never started on it.
Peer-reviewed -
Data, models and systemsAI in medicine new
A blood protein score of cellular ageing predicted death in UK Biobank
A blood protein score of cellular ageing, built in UK Biobank, predicted death and later dementia, COPD, heart attack and stroke, and changed over 18 months with exercise.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
Proteomic organ clocks tracked 16-year mortality less closely than epigenetic age
Accelerated liver, immune and heart proteomic ageing carried hazard ratios of 1.38 to 1.43 per standard deviation for 16-year mortality, below those for epigenetic age and cognition.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself new
Uncertainty in a biological age estimate is itself associated with mortality
In over 450,000 UK Biobank participants, the uncertainty of a biological age estimate was associated with mortality, multimorbidity and loss of healthspan independently of the age gap itself.
Preprint · not peer-reviewed
