Data, models and systems · What linked data reveals
refines
Hepatitis C treatment initiation in one US state's Medicaid rose as restrictions ended, but peaked at 23% for 2020 diagnoses.
Peer-reviewed
26 Oct 2026
Health today · Dementia
refines
A compulsory schooling reform showed that extra education lowered dementia incidence and weakened the link between genetic risk and dementia.
Peer-reviewed
25 Oct 2026
Behavioural science · Infection and pandemics
refines
Of 451,291 patients hospitalised for COVID-19 in 64 countries, 341,125 received antibiotics, mostly empirical WHO 'Watch' drugs.
Peer-reviewed
25 Oct 2026
Health today · Heart and stroke
refines
Childhood residential segregation appeared to delay cardiovascular disease or hypertension in White people and hasten it in Black people.
Peer-reviewed
25 Oct 2026
Data, models and systems · What linked data reveals
new
A linked cohort of 3,719,651 Scottish adults describes COVID-19 outcomes by disability group and household living arrangements.
Peer-reviewed
23 Oct 2026
Data, models and systems · What linked data reveals
contradicts
Simulations with no true interaction reproduced the reported pattern of greater lipid-lowering benefit at higher coronary artery disease polygenic risk.
Preprint · not peer-reviewed
23 Oct 2026
Data, models and systems · What linked data reveals
new
Six Thai routine-care files were linked by encrypted identifier into registry, visit and drug exposure tables.
Peer-reviewed
23 Oct 2026
Health today · Cancer
refines
Five-year overall survival was 71% in never smokers, 58% in former smokers and 49% in current smokers.
Peer-reviewed
23 Oct 2026
Health today · Frailty and multimorbidity
new
In 180,314 adults from five harmonised ageing cohorts, healthy working life expectancy at age 50 was 11.87 years for robust participants, 7.34 years for pre-frail and 3.77 years for frail.
Peer-reviewed
23 Oct 2026
Data, models and systems · What linked data reveals
refines
Emergency visits were 67% higher after a first Z59 hardship code, but an administrative code reproduced much of this.
Preprint · not peer-reviewed
18 Oct 2026
Health today · Obesity, diabetes and GLP-1
new
Recorded remission reached 3.82% at five years in treated adults, and ended more often by treatment restart than rising HbA1c.
Preprint · not peer-reviewed
18 Oct 2026
Data, models and systems · What linked data reveals
refines
Of 1,409,275 ONS-registered deaths from 2020 to 2025, 88% had the same date of death in primary care and 8% had none.
Preprint · not peer-reviewed
17 Oct 2026
Tomorrow's world · Slowing ageing itself
refines
Of six ageing measures tested against six immune-mediated diseases, only longer leukocyte telomeres lowered interstitial lung disease risk.
Preprint · not peer-reviewed
17 Oct 2026
Behavioural science · Alcohol and drug use
refines
Among 26,031 people in Austria's opioid agonist treatment registry, all-cause mortality was 7.06 times the general population rate in women and 3.86 times in men.
Peer-reviewed
16 Oct 2026
Data, models and systems · What linked data reveals
refines
Reduced CYP2D6 activity lowered attained heart rate and raised bradycardia, but phenotype was not associated with stopping metoprolol.
Peer-reviewed
16 Oct 2026
Data, models and systems · What linked data reveals
new
The Swedish research infrastructure SIMPLER brings together two cohorts, 61,433 women recruited in 1987-90 and 45,906 men in 1997, with repeated diet questionnaires, register linkage and stored biological samples.
Peer-reviewed
13 Oct 2026
Health today · Frailty and multimorbidity
new
Among 541,887 UK postmenopausal women followed for about 20 years, 60 of 99 dietary factors were associated with hip fracture risk after correction for multiple testing.
Peer-reviewed
13 Oct 2026
Behavioural science · Diet, exercise and sleep
refines
In 324,284 UK Biobank adults followed for 16 years, hip fracture risk was lowest at about one hour a day of leisure-time activity, with no further reduction at higher volumes.
Preprint · not peer-reviewed
12 Oct 2026
Data, models and systems · Health systems and access
new
Among 71,145 patients in English primary care records, those whose GP sought specialist advice before referring were diagnosed later than those referred electively, by 15.9 weeks for inflammatory bowel disease.
Preprint · not peer-reviewed
12 Oct 2026
Health today · Heart and stroke
new
Taiwan Biobank genotypes were linked to national insurance claims for 140,000 people, and those in the top 10% by polygenic risk were 3.56 times as likely to develop atrial fibrillation.
Preprint · not peer-reviewed
11 Oct 2026
Tomorrow's world · Slowing ageing itself
refines
Fine-mapping of HLA class II immune genes in 6,053 people found DRB1*04 subtypes commoner in 443 cognitively healthy centenarians, and DRB1*01:01 commoner in the 2,391 Alzheimer's patients.
Preprint · not peer-reviewed
11 Oct 2026
Data, models and systems · Health systems and access
new
Among 3,347,008 working-age adults attending emergency departments in England, stays of 12 hours or more carried 1.95 times the hospitalisation risk over two years, compared with stays under two hours.
Preprint · not peer-reviewed
10 Oct 2026
Health today · Cancer
new
In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
Preprint · not peer-reviewed
10 Oct 2026
Health today · Obesity, diabetes and GLP-1
new
Among 9,534 Danish patients with anorexia nervosa, one in seven became steadily more ill, with more psychiatric and physical illness in the five years after diagnosis.
Preprint · not peer-reviewed
6 Oct 2026
Health today · Cancer
confirms
A methylation and protein blood test identified 50.9% of cancers across 21 tumour organ types at a specificity of 98.5%, in a multi-centre case-control study of 6,352 samples.
Peer-reviewed
4 Oct 2026
Tomorrow's world · Slowing ageing itself
new
In over 450,000 UK Biobank participants, the uncertainty of a biological age estimate was associated with mortality, multimorbidity and loss of healthspan independently of the age gap itself.
Preprint · not peer-reviewed
30 Sep 2026
Behavioural science · Social connection
refines
In a 29-country European survey of 48,377 respondents, loneliness was the strongest social predictor of psychological distress, and the other social measures together added 0.006 to the AUC.
Peer-reviewed
30 Sep 2026
Health today · Dementia
refines
A study of APOE genotype against 2,632 traits and conditions in 367,757 All of Us participants found 27 associations, with dementia risk largest in those of European ancestry.
Preprint · not peer-reviewed
30 Sep 2026
Health today · Mental health
new
Exome sequencing of 21,958 cases and 19,826 controls in a Colombian founder population identified seven genes associated with serious mental illness, one variant raising risk more than threefold.
Preprint · not peer-reviewed
29 Sep 2026
Behavioural science · Adherence and persistence
refines
Of 401,450 US women starting adjuvant endocrine therapy after breast surgery, 69.9% had a medication possession ratio of at least 80% over the first year.
Preprint · not peer-reviewed
28 Sep 2026
Data, models and systems · AI in medicine
refines
Across 150 diseases in 900,000 UK Biobank and FinnGen participants, polygenic scores added most in metabolic, cardiovascular, autoimmune and neurological disease, and added little for genitourinary and respiratory conditions.
Preprint · not peer-reviewed
28 Sep 2026
Data, models and systems · What linked data reveals
new
ECHILD, which links hospital, school and social care records for 21 million children in England, includes children in deprived areas and in minoritised ethnic groups less often than others.
Preprint · not peer-reviewed
26 Sep 2026
Health today · Dementia
new
Carriers of a NOTCH3 variant causing CADASIL, an inherited small vessel brain disease, had 2.55 to 5.08 times the odds of a more impaired dementia rating than non-carrier relatives.
Preprint · not peer-reviewed
24 Sep 2026
Data, models and systems · What linked data reveals
new
In linked Scottish health and social care records, care-experienced girls had 3.22 times the risk of a first mental health admission, and boys 2.64 times, compared with the general population.
Peer-reviewed
23 Sep 2026
Behavioural science · Alcohol and drug use
refines
Among 176,719 deaths at ages 18-64 in Massachusetts and Minnesota, alcohol, drug and suicide causes accounted for 12% and 7% more of former service members' deaths than of non-military deaths.
Peer-reviewed
23 Sep 2026
Health today · Heart and stroke
refines
Among 189,770 UK Biobank participants, those with the most variable systolic readings had 33% to 54% higher risk of abdominal aortic aneurysm than those with the steadiest readings.
Peer-reviewed
23 Sep 2026
Data, models and systems · What linked data reveals
refines
Whole-genome sequencing of 1,052 UK 100,000 Genomes participants with congenital kidney and urinary tract anomalies found a single-gene cause in 4.9%, rising to 11.1% in those with cystic kidney dysplasia.
Peer-reviewed
23 Sep 2026
Health today · Dementia
refines
Across four cohorts of 3,483 participants, the intelligence-linked part of an education genetic score was inversely associated with Alzheimer's diagnosis, while the behavioural part was not.
Peer-reviewed
23 Sep 2026
Data, models and systems · Revisions and new sources
new
The Collaborative Amish Aging and Memory Project has enrolled 3,978 Amish adults in Ohio and Indiana, 2,928 with an agreed cognitive diagnosis, and reports only the cohort's composition.
Preprint · not peer-reviewed
21 Sep 2026
Health today · Dementia
new
A study of rare damaging gene variants in biobank and sequencing cohorts confirmed eight known dementia genes and newly linked IMPA2 to dementia and ANKRD27 to Parkinson's disease.
Preprint · not peer-reviewed
20 Sep 2026
Behavioural science · Diet, exercise and sleep
confirms
Among 300,875 UK Biobank adults followed for a median of 12.3 years, those meeting most of seven healthy habits had half the kidney stone risk of those meeting fewest.
Peer-reviewed
20 Sep 2026
Health today · Cancer
refines
Across 16 cancers, genome-wide analysis identified 20 correlated cancer pairs, whereas analysis region by region identified shared genetic signals across 66 pairs.
Peer-reviewed
20 Sep 2026
Health today · Cancer
refines
Across 560,287 US veterans, all 13 cancer polygenic scores were associated with their own cancer in European-ancestry participants, but only five of 13 were in African-ancestry participants.
Peer-reviewed
20 Sep 2026
Data, models and systems · What linked data reveals
new
Australian census records linked to death registrations show all-cause mortality a quarter higher among adults in same-sex than different-sex relationships, and external-cause mortality two to three times higher.
Peer-reviewed
20 Sep 2026
Data, models and systems · What linked data reveals
refines
In Austrian adults with no documented prior infection, vaccinated people had lower mortality from cancer and external causes, with adjusted all-cause hazard ratios of 0.24 to 0.32 in the two weeks after a dose, a measure of the healthy vaccinee effect.
Preprint · not peer-reviewed
14 Sep 2026
Health today · Frailty and multimorbidity
refines
In 8,711 Japanese adults, a bone density genetic score added little to age and sex, though the lowest-scoring fifth had 1.42 times the osteoporosis incidence of the middle fifth.
Peer-reviewed
11 Sep 2026