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Item new Preprint · not peer-reviewed Added

Top 10% by polygenic risk carry a fifth of Taiwan's atrial fibrillation

Taiwan Biobank genotypes were linked to national insurance claims for 140,000 people, and those in the top 10% by polygenic risk were 3.56 times as likely to develop atrial fibrillation.

The study linked Taiwan Biobank genotypes to National Health Insurance claims for 140,000 people, covering 42 non-communicable diseases. Those with the top-decile polygenic risk suffered a fifth of Taiwan's atrial fibrillation cases, and spent 24% more days in hospital.

Why it is interesting: Earlier polygenic burden estimates were European; here the claims record also shows hospital use.

Source
medRxiv, 9 October 2026
Paper
Burden of Non-Communicable Diseases Attributable to Polygenic Risk and Its Association with Healthcare Utilization in Taiwan
Authors
Shih M, Ke Y, Chang X, Wang L, Feng YA
DOI
10.64898/2026.10.07.26365010
Type
Preprint
Design
Cohort linkage of Taiwan Biobank genotypes to National Health Insurance Research Database claims, n=140,000, 42 non-communicable diseases, Cox models with population attributable fractions and DALYs
Verdict
New finding
Driver
Heart and stroke
Driver
What linked data reveals

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