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Tomorrow's worldSlowing ageing itself refines
Epigenetic clock changes correspond inconsistently to clinical changes in ageing studies
In human geroscience intervention studies, epigenetic-clock changes matched clinical-outcome changes inconsistently, and no study validated a clock as a surrogate.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Antibiotic use in patients hospitalised for COVID-19 across 64 countries, 2020 to 2023
Of 451,291 patients hospitalised for COVID-19 in 64 countries, 341,125 received antibiotics, mostly empirical WHO 'Watch' drugs.
Peer-reviewed -
Behavioural scienceSmoking and vaping refines
Switching from cigarettes to e-cigarettes and human biomarkers of toxicant exposure
Complete switching from cigarettes to e-cigarettes was linked to lower levels of all ten pooled toxicant exposure biomarkers.
Peer-reviewed -
Data, models and systemsValue in health new
HPV catch-up vaccination to age 30 modelled in 132 low- and middle-income countries
A one-time catch-up campaign for females aged 9-30 was projected to prevent 6.93 million cervical cancer cases and 3.56 million deaths.
Preprint · not peer-reviewed -
Health todayDementia refines
Lecanemab in real-world practice: pooled ARIA, discontinuation and cognitive outcomes
Any ARIA occurred in 15.1% of lecanemab-treated patients in real-world cohorts, rising to 34.1% in APOE e4 homozygotes.
Peer-reviewed -
Health todayFrailty and multimorbidity new
Frailty at 50 linked to shorter healthy working life expectancy across 33 countries
In 180,314 adults from five harmonised ageing cohorts, healthy working life expectancy at age 50 was 11.87 years for robust participants, 7.34 years for pre-frail and 3.77 years for frail.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 confirms
GLP-1 receptor agonists do not improve cognition or function in Alzheimer's disease or MCI
GLP-1 receptor agonists improved neither cognition nor disease progression in pooled trials, with more adverse events and discontinuation.
Peer-reviewed -
Data, models and systemsHealth systems and access refines
Health opportunity cost estimates updated for 92 low- and middle-income countries
The marginal cost per DALY averted ranges from about $54 to $18,547 across 92 low- and middle-income countries.
Preprint · not peer-reviewed -
Health todayDementia refines
Dementia incidence 9.7 per 1000 person-years, higher in low- and middle-income countries
Age- and sex-standardised all-cause dementia incidence was 9.7 per 1000 person-years across 22 cohorts in 18 countries.
Peer-reviewed -
Data, models and systemsHealth systems and access new
Life expectancy in 28 countries modelled by machine learning on six drivers
Machine learning on a 28-country panel found a concave income-longevity link, and projected mean life expectancy of 78.21 years in 2032 under baseline against 78.98 under an integrated prevention scenario.
Peer-reviewed -
Health todayCancer refines
Three in five women aged 30-49 have never had cervical screening
Three in five women aged 30-49 worldwide have never been screened for cervical cancer, and 92% have never had an HPV test.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Higher HPV antibody levels are associated with greater vaccine efficacy across types
A Bayesian meta-analysis of randomised HPV vaccine trials found higher type-specific antibody levels associated with greater efficacy against infection and CIN2+, with the level associated with protection differing by type.
Preprint · not peer-reviewed
