Tomorrow's world
Every aspect of our daily lives will be transformed by technology, from sensors and robotics to nanotechnology — while a changing climate and emerging microbial threats reshape the risks we face.
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Tomorrow's world posts, most recent first.
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Item refines preprint
Immunosuppressed people are less protected than their antibody levels would suggest
A meta-analysis of antibody responses to mRNA COVID-19 vaccination found binding antibody levels 54.5-fold lower in people on B-cell depleting therapy than in healthy controls, and protection against infection and hospitalisation lower at any given antibody level.
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Item confirms peer-reviewed
Carbapenem resistance tracked death in ICU-acquired bloodstream infection
Among 352 adults who developed a gram-negative bloodstream infection at least 48 hours after ICU admission, half the isolates were carbapenem-resistant and 30-day mortality was 57.9%, with resistance independently associated with death and appropriate early treatment with survival.
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Item new peer-reviewed
Carbapenemase-producing Enterobacterales doubled every 2.4 years in French hospitals
French national hospital surveillance for 2019 to 2024 found extended-spectrum beta-lactamase-producing Enterobacterales flat at 0.53 to 0.70 cases per 1,000 patient-days, while carbapenemase-producing Enterobacterales rose 32.8% a year from a far lower base, doubling every 2.4 years.
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Item new peer-reviewed
Higher particulate exposure before surgery tracked worse gastric cancer survival in China
In 4,441 patients who had radical surgery for stage I-III gastric cancer in Zhejiang, China, each standard-deviation rise in pre-surgery PM2.5 exposure was associated with 15% higher all-cause mortality and 31% higher gastric cancer-specific mortality.
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Item refines peer-reviewed
Remote exercise rehabilitation raised peak oxygen uptake in cardiac patients
A meta-analysis of 13 randomised trials in 958 adults with cardiovascular disease found exercise-based telerehabilitation improved peak oxygen uptake by 2.58 mL/kg/min against usual care, on a 95% prediction interval running from -1.28 to 6.44 and substantial heterogeneity.
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Item refines peer-reviewed
Whole-genome sequencing gave a genetic diagnosis in 4.9% of kidney anomaly cases
Whole-genome sequencing of 1,052 people with congenital anomalies of the kidney and urinary tract in the UK 100,000 Genomes Project gave a single-gene diagnosis in 4.9%, with common and low-frequency variants estimated to explain 23% of phenotypic variance.
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Item refines peer-reviewed
Particulate matter shows no overall association with venous thromboembolism
An updated meta-analysis of 19 observational studies covering more than 4.5 million people found no significant overall association between long-term particulate exposure and venous thromboembolism, with a modest one appearing only among studies reporting in the same units.
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Item refines peer-reviewed
Only the cognitive part of education's polygenic score tracks Alzheimer's disease
Across four cohorts totalling 3,483 participants, the cognitive component of an educational attainment polygenic score was inversely associated with Alzheimer's diagnosis and with Braak stage, while the non-cognitive component showed no association with any outcome.
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Item confirms peer-reviewed
A claims-wide screen of SGLT2 inhibitors in kidney disease finds no new harms
A scan of all diagnosis codes in 31,246 matched pairs of US patients with type 2 diabetes and stage III to IV chronic kidney disease found only the already-known genital infection signal for SGLT2 inhibitors against GLP-1 receptor agonists, with nothing from inpatient or emergency codes.
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Item confirms preprint
Two influenza vaccine doses in a year tracked lower hospital mortality in Brazil
Among patients hospitalised with confirmed influenza in Brazil between 2023 and October 2025, a single trivalent vaccine dose was associated with 10-13% lower adverse outcomes and two doses within a calendar year with 32% lower in-hospital mortality.
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Item confirms peer-reviewed
Cost-effectiveness of antiobesity drugs varies widely across 26 published models
A systematic review of 26 full economic evaluations of approved antiobesity medications found the results heterogeneous and highly sensitive to model assumptions, with semaglutide consistently more cost-effective than liraglutide and tirzepatide often above lower willingness-to-pay thresholds.
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Item new preprint
Peer-derived fMRI neurofeedback during a film reduced craving in opioid use disorder
A real-time fMRI study trained people with opioid use disorder to align prefrontal activity with a signal derived from peers further into recovery watching the same film, and reported reduced craving against sham feedback, in a preprint that gives no sample size.
