This study related 2013 MIND diet scores to 2016 DNA methylation measures in 1,740 Health and Retirement Study participants. Each 1-s.d. higher MIND score was associated with 0.4 years lower PhenoAge acceleration (95% CI -0.8 to -0.1). GrimAge acceleration was 0.3 years lower and methylation Pace of Aging 0.0054 lower. All three survived false-discovery-rate correction. Results held after BMI adjustment and after weighting for which participants had methylation measured. A machine-learning method, causal forests, found no subgroup that consistently benefited more than others. The design is observational, with diet and methylation each measured once, so residual confounding cannot be excluded.
Why it is interesting: Epigenetic clocks offer a way to study diet and ageing without waiting for disease or death. Three different clocks moved in the same direction, though the age-acceleration differences were under half a year.
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