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Data, models and systemsValue in health refines
Hemgenix for haemophilia B costs more than factor IX prophylaxis over the first ten years
In a Swedish budget-impact model, Hemgenix cost more than factor IX prophylaxis over 10 years under every payment model.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Weather and child hospitalisation in Sweden: heat, intraday temperature swings and rain
Among 4,638,247 Swedish children, heat, very low or very high intraday temperature swings and more rain were linked to admissions.
Preprint · not peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
GrimAge epigenetic clock predicts survival in Dutch centenarians beyond cognition
Among 247 Dutch centenarians, higher GrimAge acceleration predicted higher mortality independently of cognition; adding MMSE improved survival stratification.
Preprint · not peer-reviewed -
Health todayCancer refines
Mental health disorders and breast and bowel cancer screening and stage in Taiwan
In Taiwan, people with mental health disorders screened slightly more for breast and bowel cancer; severe cases screened less.
Peer-reviewed -
Health todayCancer new
Off-label oncology drug use spans over a third of reimbursable Dutch drug–cancer pairings
In 2023 a quarter of Dutch high-cost cancer drug prescriptions were off-label, but they made up 2.3% of spending.
Peer-reviewed -
Health todayHeart and stroke new
Home blood pressure monitoring in US veterans and later deaths and cardiovascular events
In 30,203 veterans using home blood pressure monitoring and 30,096 matched controls, monitoring was linked to 8% lower all-cause mortality.
Preprint · not peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
Epigenetic clock changes correspond inconsistently to clinical changes in ageing studies
In human geroscience intervention studies, epigenetic-clock changes matched clinical-outcome changes inconsistently, and no study validated a clock as a surrogate.
Peer-reviewed -
Tomorrow's worldA changing climate new
Typhoon exposure and excess deaths in Japan, 2010–2019, by age and local vulnerability
Typhoon winds were linked to 2,426 excess deaths among Japanese adults aged 70 and over, against 301 recorded direct deaths.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
Heat-attributable mortality in Spain rose 15% per 1 °C of mean heatwave daily Tmax
Event-level heat metrics explained much of the variability in heatwave mortality, while heat-attributable deaths fell 3.9-5.8% a year after adjusting for temperature.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Temperature-attributable cardiovascular deaths in Europe may double by late century
Under high emissions, temperature-attributable cardiovascular deaths in Europe rise from 31.4 to 62.4 per 100,000, with heat-attributable rates up 472%.
Peer-reviewed -
Data, models and systemsAI in medicine new
FAHR-Face, a face photograph foundation model, estimates biological age and survival
A face photograph model fine-tuned on 34,363 patients with cancer separated mortality risk between quartiles.
Peer-reviewed -
Data, models and systemsAI in medicine new
Long-term ozone and stroke risk in 20 757 Polish patients with atrial fibrillation
In Polish patients with atrial fibrillation, each interquartile rise in ozone was associated with a 27% higher composite stroke risk.
Peer-reviewed
