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Health todayFrailty and multimorbidity refines
Plant-based diet indices and frailty in 8,628 older adults across three ageing cohorts
Higher overall plant-based scores were associated with lower frailty risk (ORs 0.71-0.80), unhealthful scores with higher risk (1.24-1.41).
Peer-reviewed -
Data, models and systemsValue in health new
Enzalutamide in prostate cancer costs AUD$835,580 per QALY in ENZAMET trial analysis
Adding enzalutamide in the ENZAMET trial cost AUD$835,580 per QALY gained, far above the AUD$50,000 threshold.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Temperature-related mortality across 3,116 Dutch districts is dominated by cold, not heat
Cold was associated with 11,988 excess deaths a year in the Netherlands, heat with 346.
Peer-reviewed -
Tomorrow's worldA changing climate new
Drought-attributable excess mortality in Somalia, 2015-2024: a small-area modelling study
Modelling estimated 71,100 excess deaths in Somalia during the 2022-2024 drought, 91% of them children under 5.
Peer-reviewed -
Tomorrow's worldA changing climate contradicts
Wildfire smoke PM2.5 in US counties: excess deaths peak three years after exposure
Monthly county-level wildfire PM2.5 and mortality data gave 1.7 million smoke-associated deaths over 2011-2023, about ten times conventional estimates.
Preprint · not peer-reviewed -
Tomorrow's worldChanging behaviour at scale refines
Since 2021, low vaccine coverage predicts larger measles outbreaks in US counties
Since 2021, US counties with lower vaccine coverage have had larger measles outbreaks, and spread to neighbouring counties has increased.
Preprint · not peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
Short telomeres, not epigenetic or proteomic ageing, raise interstitial lung disease risk
Of six ageing measures tested against six immune-mediated diseases, only longer leukocyte telomeres lowered interstitial lung disease risk.
Preprint · not peer-reviewed -
Tomorrow's worldInnovation in treatment new
VES001, an oral sortilin inhibitor, raised plasma and CSF progranulin in healthy adults
In a randomised placebo-controlled first-in-human trial, twice-daily oral VES001 for 7 days raised plasma progranulin by up to 49% and CSF progranulin by 18% from baseline.
Peer-reviewed -
Data, models and systemsValue in health new
NHS online diabetes self-management service modelled at £13,192 per QALY
A patient-level simulation of an NHS online service for type 2 diabetes estimated a gain of 0.016 QALYs and a net cost of £216 per user.
Peer-reviewed -
Tomorrow's worldInnovation in treatment new
BCG immunotherapy lowers HbA1c for up to eight years in long-standing type 1 diabetes
HbA1c fell 7.04% from baseline at year 5 and 12.84% at year 8 with BCG, unchanged on placebo.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate new
More days above the WHO daily NO2 guideline are followed by faster cognitive decline
Among 12,235 English adults aged 50 and over, more days above the WHO daily NO2 guideline were followed by faster decline in memory and fluency, independent of annual mean exposure.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
Wildfire smoke PM2.5 is associated with higher dementia incidence in older US adults
Each microgram per cubic metre of wildfire smoke PM2.5 was associated with a 2.9% increase in the incidence rate of dementia among 39.7 million US Medicare beneficiaries followed to 2019.
Preprint · not peer-reviewed
