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Tomorrow's worldSlowing ageing itself refines
Immune gene HLA-DRB1*04 is commoner in centenarians, DRB1*01:01 in Alzheimer's patients
Fine-mapping of HLA class II immune genes in 6,053 people found DRB1*04 subtypes commoner in 443 cognitively healthy centenarians, and DRB1*01:01 commoner in the 2,391 Alzheimer's patients.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
Summer heat in Italy raises deaths from nervous system and mental illness
Across 7,864 Italian municipalities over 20 summers, heat-attributable fractions were highest for nervous system diseases at 14.93% and mental and behavioural disorders at 14.47%.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep new
Weight-management texts did not reduce weight in postpartum women over 12 months
Among 892 postpartum women with a BMI of 25 or more, 12 months of automated weight-management texts made no difference to weight against texts on child health (-0.1 kg).
Preprint · not peer-reviewed -
Health todayCancer new
Menopausal hormone therapy users had higher breast cancer incidence but lower mortality
In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
Preprint · not peer-reviewed -
Tomorrow's worldMedicine at a distance new
Older patients on a virtual ward reported fewer depressive symptoms than inpatients
Among 100 patients aged 70 and over, 72% of hospital inpatients screened positive for depressive symptoms as compared to 30% of those cared for on a virtual ward.
Peer-reviewed -
Health todayCancer new
PSMA-guided radiotherapy did not improve failure-free survival in prostate cancer
In a phase 2 trial of 253 men, radiotherapy targeted to every lesion seen on PSMA-PET gave five-year failure-free survival of 66% against 62% for standard care.
Peer-reviewed -
Tomorrow's worldInnovation in treatment new
Oral orforglipron is tested for cardiovascular safety against insulin in type 2 diabetes
A phase 3 trial randomised 2749 adults with type 2 diabetes and heart or kidney disease to oral orforglipron or insulin glargine, and followed them for a median two years.
Peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Systolic pressure was 5.8 mmHg lower with apps and wearables after stroke
Across 29 studies in 8,389 stroke and transient ischaemic attack survivors, systolic blood pressure was 5.8 mmHg lower with mobile applications or wearables, though prediction intervals crossed the null.
Peer-reviewed -
Data, models and systemsAI in medicine new
A blood protein score of cellular ageing predicted death in UK Biobank
A blood protein score of cellular ageing, built in UK Biobank, predicted death and later dementia, COPD, heart attack and stroke, and changed over 18 months with exercise.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself refines
Proteomic organ clocks tracked 16-year mortality less closely than epigenetic age
Accelerated liver, immune and heart proteomic ageing carried hazard ratios of 1.38 to 1.43 per standard deviation for 16-year mortality, below those for epigenetic age and cognition.
Peer-reviewed -
Tomorrow's worldA changing climate new
Daily cancer deaths in Japan were 0.88% higher per 10 micrograms/m3 of PM2.5
A 10 microgram per cubic metre rise in PM2.5 was associated with 0.88% more cancer deaths in Japan, though the association did not survive adjustment for NO2 or SO2.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself new
Uncertainty in a biological age estimate is itself associated with mortality
In over 450,000 UK Biobank participants, the uncertainty of a biological age estimate was associated with mortality, multimorbidity and loss of healthspan independently of the age gap itself.
Preprint · not peer-reviewed
