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Tomorrow's worldA changing climate refines
Heat-attributable mortality in Spain rose 15% per 1 °C of mean heatwave daily Tmax
Event-level heat metrics explained much of the variability in heatwave mortality, while heat-attributable deaths fell 3.9-5.8% a year after adjusting for temperature.
Peer-reviewed -
Health todayDementia new
Amyloid and tau stage in 2711 Sao Paulo autopsies, by age and cognitive status
In 2711 Sao Paulo autopsies, 19.6% had both amyloid and tau at biomarker-detectable levels, rising steeply with age.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
HPV catch-up vaccination to age 30 modelled in 132 low- and middle-income countries
A one-time catch-up campaign for females aged 9-30 was projected to prevent 6.93 million cervical cancer cases and 3.56 million deaths.
Preprint · not peer-reviewed -
Tomorrow's worldA changing climate refines
Temperature-attributable cardiovascular deaths in Europe may double by late century
Under high emissions, temperature-attributable cardiovascular deaths in Europe rise from 31.4 to 62.4 per 100,000, with heat-attributable rates up 472%.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Anti-obesity drugs in routine care: short exposure, smaller weight loss than in trials
In routine care, nearly half of tirzepatide users did not reach 10% weight loss after at least 72 weeks.
Peer-reviewed -
Data, models and systemsWhat linked data reveals new
Scottish cohort of 3.7 million adults links disability and household setting to COVID-19
A linked cohort of 3,719,651 Scottish adults describes COVID-19 outcomes by disability group and household living arrangements.
Peer-reviewed -
Data, models and systemsValue in health new
Perioperative enfortumab vedotin and pembrolizumab in cisplatin-ineligible bladder cancer
In a Markov model, perioperative enfortumab vedotin plus pembrolizumab cost $72,460 per QALY gained versus radical cystectomy alone.
Peer-reviewed -
Data, models and systemsAI in medicine new
FAHR-Face, a face photograph foundation model, estimates biological age and survival
A face photograph model fine-tuned on 34,363 patients with cancer separated mortality risk between quartiles.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
Semaglutide: 14.5% of US initiators start at high dose, with earlier discontinuation
Among US adults starting injectable semaglutide, high-dose initiation was associated with a 25% higher early discontinuation risk and lower 1-year persistence.
Peer-reviewed -
Health todayCancer refines
HPV-attributable fraction in oropharyngeal cancer rose in seven countries over a decade
Central testing of 6,043 head and neck cancer specimens found HPV attributability in oropharyngeal cancer rose in all seven countries.
Peer-reviewed -
Data, models and systemsValue in health new
Housing for homeless Californians with opioid use disorder modelled at $31,083 per QALY
A lifetime microsimulation of 18,928 Californians experiencing homelessness with opioid use disorder gave $31,083 per quality-adjusted life-year from expanding housing access.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals contradicts
Polygenic modification of statin benefit may arise from trial eligibility criteria
Simulations with no true interaction reproduced the reported pattern of greater lipid-lowering benefit at higher coronary artery disease polygenic risk.
Preprint · not peer-reviewed
