-
Item new preprint
A generative model of patient records stratifies five-year risk of first cancer
A preprint describes an autoregressive generative model trained on electronic health records from millions of patients, reporting that supervised adaptation improved prediction of a first cancer diagnosis within five years across five cohorts.
-
Item confirms peer-reviewed
RSV hospitalisations in older Brazilians rose after 2020, with case fatality 21-31%
National surveillance records show RSV-associated severe acute respiratory infection hospitalisations in Brazilians aged 60 and over rose from under 1 to over 15 per 100,000 between 2013 and 2024, with in-hospital case fatality of 21-31% and a mean stay of 12.9 days.
-
Item refines peer-reviewed
PSA density stratifies later significant prostate cancer risk after a negative MRI
Among 1,685 Swedish men with a negative prostate MRI in the Gothenburg-2 screening trial, seven-year cumulative incidence of clinically significant prostate cancer was 5.5% where baseline PSA density was below 0.10 ng/mL2, against 13.8% and 11.9% in the higher bands.
-
Item refines peer-reviewed
Scotland's post-pandemic invasive strep A surge involved no new hypervirulent clone
Surveillance of 3,408 invasive group A streptococcus infections in Scotland from 2014 to 2024, with whole-genome sequencing of 404 emm1 isolates, found the late-2022 surge coincided with influenza and RSV activity rather than a genetically distinct clone.
-
Item new peer-reviewed
Norway's ischaemic stroke fall over two decades left AF-related stroke unchanged
Norwegian national registry data on 227,575 incident strokes from 2001 to 2021 show non-AF ischaemic stroke falling from 204.4 to 130.8 per 100,000 person-years while atrial-fibrillation-related ischaemic stroke stayed flat at about 68.
-
Item new peer-reviewed
Combined GLP-1 and SGLT2 use was linked to lower mortality after AF ablation, not less AF
In propensity-matched US health records for 2018 to 2024, atrial fibrillation recurrence after catheter ablation was similar whether patients took a GLP-1 receptor agonist, an SGLT2 inhibitor or both, while all-cause mortality was 40% to 46% lower with the combination, on small numbers of deaths.
-
Item refines peer-reviewed
H-FABP discriminated coronary disease poorly (AUC 0.56) but tracked eight-year mortality
In 2,690 patients with suspected functionally relevant coronary artery disease, heart-type fatty acid-binding protein discriminated poorly at diagnosis (AUC 0.56), yet eight-year all-cause mortality ranged from 7.7% in its lowest quartile to 44% in the highest.
-
Item refines peer-reviewed
Adolescent movement behaviours explained 2.0 points of a 6.9-point CVD risk gap
In 6,608 US adolescents followed for over two decades, the 6.9 percentage-point gap in predicted 30-year cardiovascular risk by parental education fell to 4.9 points in a scenario removing all unhealthy physical activity, screen time and sleep, and the relative gap was unchanged.
-
Item confirms peer-reviewed
A Chinese dual GLP-1/GIP agonist produced 11% to 18% weight loss at 24 weeks in phase 2
In a 120-participant phase 2 trial in Chinese adults with overweight or obesity and no diabetes, once-weekly BGM0504 produced mean weight loss of 10.7% to 18.3% across three doses at 24 weeks, against a 0.1% gain on placebo, with mostly gastrointestinal adverse events rising with dose.
-
Item refines peer-reviewed
FAP relatives found by family screening had a median SMR of 0.66, symptomatic cases 11.09
In a UK registry of 1,917 people with familial adenomatous polyposis, relatives identified through family screening had mortality comparable to the general population (median SMR 0.66), while those presenting with symptoms had a median SMR of 11.09.
-
Item refines preprint
Plasma p-tau217 tracked Alzheimer's-type atrophy but not general brain ageing
In 818 cognitively unimpaired participants of the Baltimore Longitudinal Study of Aging, plasma p-tau217 measured before symptoms was associated with later mild cognitive impairment or dementia due to Alzheimer's disease and was the only marker associated with medial temporal lobe atrophy.
-
Item new peer-reviewed
An enriched Head Start programme improved 7 of 11 well-being measures at ages 21 to 22
A randomised trial that added intensive social-emotional and language support to Head Start classrooms for 356 low-income four-year-olds found benefits on 7 of 11 well-being measures at ages 21 to 22, including loneliness, depressive symptoms and conduct problems.
