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Item new preprint
Daraxonrasib is estimated at $500,637 per QALY in pancreatic cancer at US launch price
A modelled economic evaluation of daraxonrasib in previously treated metastatic pancreatic adenocarcinoma estimated 0.506 additional QALYs at an incremental cost of $253,171, or $500,637 per QALY at the $39,800 monthly launch price, in a preprint not yet peer reviewed.
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Item refines peer-reviewed
Cancer polygenic scores were weaker in African-ancestry than European-ancestry veterans
Among 560,287 US veterans, all 13 cancer-specific polygenic risk scores were associated with their own cancer in European-ancestry participants (OR 1.05 to 1.70 per standard deviation), but only 5 of 13 reached significance in African-ancestry participants, with smaller effects (OR 1.01 to 1.48).
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Item new peer-reviewed
Women and deprived patients had higher one-year mortality in English aortic disease
Among 33,793 new thoracic aortic disease diagnoses in England between 2013 and 2018, one-year mortality was higher among women, older patients and those from deprived areas, and patients from deprived areas were less likely to receive early intervention or genetic referral.
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Item new peer-reviewed
1 in 4 Black US students left a suicide-injury survey item blank, against 1 in 10 white
Across 163,489 US high school students surveyed between 2001 and 2021, 11.1% left the suicide-attempt item blank and 13.9% the injury item, with injury missingness averaging 25.8% among Black adolescents against 9.7% among white adolescents.
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Item confirms peer-reviewed
Cardiac rehabilitation cut heart attacks by 28% and admissions by 35% across 107 trials
An updated Cochrane review of 107 randomised trials in 26,886 adults with coronary heart disease found that exercise-based cardiac rehabilitation reduced myocardial infarction (RR 0.72, 95% CI 0.54 to 0.95) and all-cause hospital admission (RR 0.65, 0.51 to 0.82) at 6 to 12 months.
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Item confirms preprint
AT2-stimulating antihypertensives were linked to less dementia in two US cohorts
In 1.6 million Medicare beneficiaries and 80,267 Vanderbilt patients aged 65 and over with hypertension, incident Alzheimer's disease and related dementias were less common among users of angiotensin II receptor-stimulating than receptor-inhibiting antihypertensives (6.7% against 8.2% in Medicare).
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Item new peer-reviewed
Mortality was about a quarter higher for Australians in same-sex relationships
Australian census records linked to death registrations for 2011 to 2023 show all-cause mortality about a quarter higher among adults in same-sex than different-sex relationships, and external-cause mortality two to three times higher, both before and after the 2017 marriage reform.
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Item confirms peer-reviewed
31% of US adults starting a GLP-1 drug for obesity were persistent users over 12 months
Among 201,229 commercially insured US adults with obesity and no diabetes who started a GLP-1 receptor agonist, 30.7% followed a persistent-use trajectory over 12 months and 43.1% had discontinued within the first half-year, with 20.3% persistent among 1,139 paediatric initiators.
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Item new preprint
PCV21 would prevent 1.5–1.7 times as many pneumococcal cases as PCV20 in Japan
Combining Japanese adult invasive pneumococcal disease surveillance with a multicentre pneumonia study, the authors estimate that PCV21 would prevent 1.5–1.7 times as many pneumococcal disease cases as PCV20 among adults aged 65 and over at current 40% coverage.
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Item refines preprint
Self-guided lipid app cut LDL-cholesterol by 3.9% more than usual care over six months
In a pragmatic online trial of 278 adults with LDL-cholesterol above their risk-adapted target, a fully self-guided lifestyle app added to usual care reduced LDL by 3.9% more than usual care alone at six months, with 41.7% versus 23.8% achieving a fall of at least 10%.
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Item new peer-reviewed
Fine particulate matter shows no association with ovarian cancer across pooled cohorts
A systematic review of 145 studies of environmental chemical exposures and gynaecologic cancers found no pooled association between PM2.5 and ovarian cancer (HR 1.02 per 5 µg/m³, 95% CI 0.91–1.13) and only a marginal one for endometrial cancer (HR 1.02, 95% CI 0.99–1.05).
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Item confirms preprint
Socioeconomic advantage tracks slower biological ageing across 12 European countries
In SHARE, three Klemera-Doubal biological-age measures predicted functional limitation, cognition and mortality, and every indicator of socioeconomic advantage was associated with lower age acceleration, though the size of the gradient differed markedly between countries.
