An Amish founder-population cohort links genomes and cognition in 3,978 older adults

The Collaborative Amish Aging and Memory Project has enrolled 3,978 older Amish adults in Ohio and Indiana, 2,928 with consensus-adjudicated cognitive status, alongside multigenerational pedigrees, whole-genome sequencing and plasma biomarkers, and reports no findings beyond its composition.

CAAMP is a longitudinal study of cognition and age-related traits in Amish communities across sites in Ohio and Indiana. Of 3,978 participants (mean age 78.6, 59.1% female), 2,928 have adjudicated cognitive status, of whom 66.6% are unimpaired, 9.9% have mild cognitive impairment, 8.9% Alzheimer disease and 4.5% another cognitive impairment. The resource links clinical and cognitive assessment to genealogies, genotyping, whole-genome sequencing and plasma biomarkers.

What you could now answer: A founder population with deep pedigrees and sequencing offers a route to genetic factors in dementia risk and protection.

Source: medRxiv
Coverage: Amish communities in Ohio and Indiana, United States; 3,978 participants, mean age 78.6; enrolment ongoing, start year not stated
Granularity: Individual-level clinical and cognitive assessment with consensus-adjudicated diagnosis, pedigree, genome-wide genotype, whole-genome sequencing, plasma biomarkers; repeat visits for subsets
Latency: not stated
Access: not stated
Change: New source
Driver: What linked data reveals
Driver: Dementia
Driver: Biotechnology against inherited risk and ageing

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