Researchers ran genome-wide association studies in 80,639 children from the Japan Environment and Children's Study birth cohort. Cord blood genotypes were analysed with questionnaires and measurements collected from pregnancy to age 4. Across 1,255 child and parental exposure traits, they found 6,073 common loci, about 18-20% of them new associations. Of these, 2,332 met a stricter significance threshold set to allow for testing so many traits. A longitudinal GWAS of BMI found 158 independent loci, 41 of which separate analyses at each age missed. Measures of child health and development cover only the first 4 years of life.
Why it is interesting: Genetic data are paired with repeated measures from pregnancy through early childhood in one nationwide cohort. The longitudinal BMI analysis found loci that separate analyses at each age did not.
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