A polygenic score for heel ultrasound bone density was built in up to 10,794 Tohoku Medical Megabank participants and validated in 8,711 others. Adding the score to age and sex improved discrimination only modestly. Over a mean 3.5 years, the lowest-scoring fifth had 1.42 times the osteoporosis incidence of the middle fifth, and the highest-scoring fifth 0.70 times.
Why it is interesting: Scores built in Japanese data separate risk groups, but add little to what age and sex already give.
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