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Item new preprint
A frameshift variant in ADAP1 more than triples serious mental illness risk in Colombia
Exome sequencing of 21,958 cases and 19,826 controls in the Paisa founder population of Colombia found seven genes associated transdiagnostically with serious mental illness, led by an ADAP1 frameshift variant that raises risk of schizophrenia and bipolar disorder more than threefold.